Oxidative damage under As3+ and/or Cu2+ stress leads to apoptosis and autophagy and may be cross-talking with mitochondrial disorders in bursa of Fabricius.

In conclusion, apoptosis and autophagy of BF induced by As3+ and Cu2+ and mitochondrial disorder are closely related to the collapse of antioxidant system, and their connections are inseparable. Our results provide a reference for environmental risk prevention and selection of poultry feed additives and pesticides to avoid the health risks caused by As3+ and Cu2+ exposure.
PMID: 31945648 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - January 6, 2020 Category: Biochemistry Authors: Guo M, Wang Y, Zhao H, Mu M, Yang X, Fei D, Liu Y, Zong H, Xing M Tags: J Inorg Biochem Source Type: research