Long-term risks cast further doubt on the use of Viagra for fetal therapy

(University of Manchester) University of Manchester scientists investigating a possible treatment for fetal growth restriction (FGR), a condition in which babies grow poorly in the womb, have urged further caution on the use of Viagra.The drug, commonly used to treat erectile dysfunction, as it enhances blood flow -- has been undergoing trials as a potential treatment for FGR. However, in a recent study in mice, Viagra showed no improvement in fetal growth but did result in high blood pressure in the pups as they reached maturity.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Resistance toward current and new classes of anti-tuberculosis (anti-TB) antibiotics are rapidly emerging; thus, innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising novel approaches for shortening therapy regimens without inducing drug resistance. Development of new TB drugs is lengthy and expensive, and success is not guaranteed; thus, alternatives are needed. Repurposed drugs have already passed Food and Drug Administration (FDA) as well as European Medicines Agency (EMA) safety requirements and may only need to prove efficacy against Mycobacterium tuberculosis (M.tb). Pho...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionWe observed significant association between the low-IIEF-5 and high-IIEF-5 groups inAlistipes andClostoridium XVIII. Further study is necessary to access the causal relationship between the gut microbiome and ED.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
AbstractPurpose of ReviewMany aspects of reproduction have been associated with increased blood pressure and impaired glucose metabolism that reveals a subsequent increased risk of cardiovascular disease. The aim of this review is to assess reproductive life factors associated with an increased risk of hypertension and cardiovascular disease, e.g., early life programming, sexual, and reproductive health in men and women.Recent FindingsImpaired fetal growth, with low birth weight adjusted for gestational age, has been found associated with hypertension in adulthood. Erectile dysfunction, currently considered an early diagno...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
ConclusionBoth smoking and BMI are strong risk factors for ED and affect response to ICI and penile duplex parameters (PSV, EDV, RI). Smoking and BMI together cause more deterioration of penile duplex parameters and response to ICI. The effect of smoking on EDV and RI was more than BMI. The effect of BMI on PSV, response to ICI and testosterone levels was more than smoking.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
AbstractGlaucoma is a leading cause of bilateral blindness. Phosphodiesterase type 5 inhibitors (PDE5Is; e.g. avanafil, sildenafil, tadalafil and vardenafil) may increase blood flow to the ciliary body, thereby elevating intraocular pressure and increasing the risk of glaucoma. PDE5Is are commonly used to treat erectile dysfunction, as well as benign prostatic hyperplasia (tadalafil) and pulmonary hypertension (sildenafil). Patients receiving PDE5Is require glaucoma education and ongoing screening, especially if they are taking a high dosage of a daily PDE5I or have risk factors for glaucoma (e.g. increased age, African-Am...
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
This article reviews the anatomic, functional, and neurochemical organization of the sympathetic and parasympathetic outputs; the effects on target organs; the central mechanisms controlling autonomic function; and the pathophysiologic basis for core symptoms of autonomic failure. RECENT FINDINGS Functional neuroimaging studies have elucidated the areas involved in central control of autonomic function in humans. Optogenetic and other novel approaches in animal experiments have provided new insights into the role of these areas in autonomic control across behavioral states, including stress and the sleep-wake cycle. SU...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
Sildenafil citrate is a vasodilator used in erectile dysfunction and pulmonary hypertension. We tested whether it reduces emergency operative births for fetal compromise and improves fetal or utero-placental perfusion in labor in a Phase II double blind randomized controlled trial.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Report of Major Impact Source Type: research
Abstract Nitric oxide (NO) is a gaseous molecule that plays a multifactorial role in several cellular processes. In the central nervous system, the NO dual nature in neuroprotection and neurotoxicity has been explored to unveil its involvement in Alzheimer's disease (AD). A growing body of research shows that the activation of the NO signaling pathway leading to the phosphorylation of the transcription factor cyclic adenine monophosphate responsive element binding protein (CREB) (so-called NO/cGMP/PKG/CREB signaling pathway) ameliorates altered neuroplasticity and memory deficits in AD animal models. In addition t...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
(University of Manchester) University of Manchester scientists investigating a possible treatment for foetal growth restriction (FGR), a condition in which babies grow poorly in the womb, have urged further caution on the use of Viagra.The drug, commonly used to treat erectile dysfunction, as it enhances blood flow - has been undergoing trials as a potential treatment for FGR. However, in a recent study in mice, Viagra showed no improvement in foetal growth but did result in high blood pressure in the pups as they reached maturity.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusion: CHA2DS2-VASc score can be used to detect Erectile dysfunction in patients who are admitted to the cardiology outpatient clinics.
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
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