Anti-leucine-rich Glioma Inactivated-1 Encephalitis Associated with Essential Thrombocythemia.
Anti-leucine-rich Glioma Inactivated-1 Encephalitis Associated with Essential Thrombocythemia.
Intern Med. 2020;59(2):271-275
Authors: Yuan X, Man X, Zhang J, Sun J, Liang J, Ma H, Tao S, Guo D, Liu L
Abstract
Anti-leucine-rich glioma inactivated-1 (anti-LGI1) encephalitis is a subgroup of autoimmune encephalitis. We herein report the case of a 60-year-old man who presented with typical symptoms, including short-term memory loss, mental abnormalities, hyponatremia and seizures characterized by faciobrachial dystonic seizures and who was diagnosed with anti-LGI1 encephalitis. At the same time, he was diagnosed with essential thrombocythemia. A significant improvement was obtained by treatment with corticosteroid, immunoglobulin, mycophenolate mofetil, and hydroxyurea. Autoimmune diseases are associated with a significantly increased risk of developing myeloproliferative neoplasms, which may explain the coexistence of anti-LGI1 encephalitis and essential thrombocythema in this patient; however, but more cases and studies are needed to determine whether there is any correlation between these conditions.
PMID: 31941873 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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