Review of Maintence Treatment in mCRC Highlights Need for Shared Decision Making

Although researchers determined which regimen was preferred among physicians in treating metastatic colorectal cancer, they found that shared decision-making should include observation as an acceptable option.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news

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Conclusion Based on the RR, Conv R, and symptom palliation ability, mFOLFOXIRI+α was suggested to be a viable candidate for first-line treatment for patients with ARCC, especially those with a high tumor burden. PMID: 32074573 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractColorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti ‐CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial effects to inhibit CRC cells via an antiproliferative mecha nism. Based on the metastatic characteristics of staging CRC, anti‐invasive and antimetastatic pharmacological activities using genistein remain uninvestigated. The scientif...
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research
Publication date: 25 April 2020Source: Journal of Industrial and Engineering Chemistry, Volume 84Author(s): Nea Young Chun, Se-Na Kim, Youn Seo Choi, Young Bin ChoyAbstractColorectal cancer is the second leading cause of cancer-related deaths worldwide. CRC is often treated with intravenous 5-fluorouracil (5FU). However, 5FU frequently shows low therapeutic efficacy and serious adverse events. Particulate drug carriers able to enhance intracellular delivery could be advantageous, since higher 5FU concentrations would be engulfed by cancer cells during a relatively short residence within the rectal space to improve local an...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
ConclusionPerforming a colon conduit in patients undergoing total pelvic exenteration for LARC or LRRC avoids the risks of ileo-ileal anastomotic leakage and may reduce the risk of a post-operative ileus. Besides, there are no other differences in outcome for ileal and colon conduits.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
We present our experience of sequential Y90 RE and portal vein embolization.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 26 Source Type: research
Clinical efficacy of Yttrium-90 (Y90) radioembolization (TARE) for patients with chemotherapy-refractory metastatic colorectal cancer (mCRC) is limited by extrahepatic disease progression, which may occur while patients are treated with sequential lobar TARE. TAS-102 (trifluride and tipiracil) has overall survival benefit for patients with refractory mCRC and may be a radiosensitizer. We aimed to evaluate the safety of the combination of TAS-102 and Y90 resin TARE in a Phase I dose-escalation trial.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 26 Source Type: research
This study assessed the efficacy of adding Y90 radioembolization to systemic therapy in patients with metastatic colorectal cancer to the liver.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 26 Source Type: research
To quantify the expression of co-inhibitory and functional molecules by tumor infiltrating CD8+ T cells in a murine heterotopic colorectal cancer model after combinational therapy of cryoablation with a dual immune checkpoint blockade (DICB).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 21 Source Type: research
Microwave ablation (MWA) has been shown to be effective in treatment of primary hepatic cellular carcinoma (HCC) and liver metastasis from colorectal cancer. The purpose of this study is to demonstrate the safety and efficacy of MWA of liver lesions including primary HCC and liver metastasis with final ablation zone that is ≤ 5 mm from the pericardium.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 14 Source Type: research
Right-sided primary (RSP) metastatic colorectal cancer (mCRC) is a poor prognostic factor compared with left-sided primary (LSP) tumor. No overall survival (OS) benefit was seen with transarterial radioembolization (TARE) as a first line therapy in the SIRFLOX, FOXFIRE Global, and FOXFIRE studies. However, a metaanalysis demonstrated a survival advantage for RSP patients. Little data exists between RSP and LSP outcomes when TARE is used as second- or third-line therapy. This retrospective analysis offers preliminary data on the differences between RSP and LSP mCRC treated with TARE.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific e-Poster Source Type: research
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