Bacteriocin production by mucosal bacteria in current and previous colorectal neoplasia

Optimal therapy for colorectal carcinoma (CRC), a frequently diagnosed malignancy, does not exist. Some of colicins and microcins, ribosomally synthesized peptides by gramnegative bacteria, have shown signific...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research

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AbstractColorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti ‐CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial effects to inhibit CRC cells via an antiproliferative mecha nism. Based on the metastatic characteristics of staging CRC, anti‐invasive and antimetastatic pharmacological activities using genistein remain uninvestigated. The scientif...
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research
We present our experience of sequential Y90 RE and portal vein embolization.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 26 Source Type: research
Microwave ablation (MWA) has been shown to be effective in treatment of primary hepatic cellular carcinoma (HCC) and liver metastasis from colorectal cancer. The purpose of this study is to demonstrate the safety and efficacy of MWA of liver lesions including primary HCC and liver metastasis with final ablation zone that is ≤ 5 mm from the pericardium.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 14 Source Type: research
Molecules, Vol. 25, Pages 964: Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis‐ Inducing Effects on Human Leukemic Cells Molecules doi: 10.3390/molecules25040964 Authors: Koutova Kulhava Havelek Majorosova Královec Habartova Hošťálková Opletal Cahlikova Řezáčová Bersavine is the new bisbenzylisoquinoline alkaloid isolated from the Berberis vulgaris L.(Berberidaceae) plant. The results of cytotoxicity screening 48 h post‐treatment showed thatbersavine considerably inhibits the proliferatio...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractWith the great success of anti-CTLA-4 and anti-PD-1 therapeutics in cancer immunotherapy, tumor necrosis factor receptor superfamily members have been recognized as ideal targets to provide co-stimulatory signals in combination with immune checkpoint blocking antibodies. Among these is OX40 (CD134), a co-stimulatory molecule expressed by activated immune cells. Recently, several anti-OX40 agonistic monoclonal antibodies, pogalizumab as the most advanced, have entered early phase clinical trials. Using a  yeast platform and multiple screening methods, we identified a fully human anti-OX40 antibody (IBI101) with...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 17 February 2020Source: International Journal of PharmaceuticsAuthor(s): Amin Afkhami-Poostchi, Mansour Mashreghi, Mehrdad Iranshahi, Maryam M. MatinAbstractBacteria-directed enzyme prodrug therapy (BDEPT), is an emerging alternative directed and tumor-specific approach. The basis of this method is the conversion of a non-toxic prodrug by a bacterial enzyme to a toxic drug within the tumor-microenvironment (TME). In the present study, the therapeutic efficacy of BDEPT was investigated based on the ability of Escherichia coli DH5α-lux/βG in activation of glycyrrhizic acid (GL), ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
We describe two cases of nasal metastases from colorectal carcinoma, and discuss the presentation, diagnosis and management of the case. Such metastatic disease ultimately represents end-stage malignancy, and patients should be palliated. PMID: 32054259 [PubMed - as supplied by publisher]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Abstract Oncolytic viruses are promising immunoreagents. Numerous studies have shown that oncolytic virotherapy is effective for many tumors. Herein, we investigated the therapeutic effect of oHSV2, an oncolytic type 2 herpes simplex virus, on mouse colon carcinoma. The in vivo antitumor efficacy of oHSV2 was observed in both unilateral and bilateral colon cancer models. oHSV2 effectively eliminated tumors and prolonged the survival of mice without side effects. Additionally, treatment with oHSV2 effectively prevented the growth of rechallenged tumors and distant implanted tumors. The specific killing ability...
Source: Herpes - Category: Infectious Diseases Authors: Tags: Mol Ther Oncolytics Source Type: research
In conclusion, MIAT was frequently overexpressed in CCA. MIAT contributed to the growth of CCA cells by targeting miR-551b-3p/CCND1 axis. PMID: 32064660 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
In conclusion, glucose metabolites from CRC triggered distinct changes in the cytokine profiles in macrophages. The downregulation of death-inducing TNFα and upregulation of Th1/17-polarizing IL-12/IL-23 axis in macrophages caused by exposure to cancer-derived glucose metabolites may contribute to tumor progression. PMID: 32056981 [PubMed - in process]
Source: The Chinese Journal of Physiology - Category: Physiology Tags: Chin J Physiol Source Type: research
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