Facile hydrothermal bio-synthesis of cellulose acetate templated CuS nanorods like fibres: antibacterial, cytotoxicity effects and DNA cleavage properties against A549 lung cancer cells

In this research, the hydrothermal method was used for synthesising cellulose acetate (CA) templated nanorods like CuS fibres using vegetable extract (Brassica oleracea var. italica). These extracts act as a reducing agent in the presence of CA. Surprisingly, when the same reaction was carried out in the absence of CA and broccoli extract, structural morphology disappeared and was found as agglomerated. In the presence of cellulose templated extract mediated CuS has revealed as nanorods like fibres and was confirmed by field emission scanning electron microscope analysis. Their crystallinity property of CuS nanoparticles (NPs) and cellulose templated biosynthesised CuS NPs was analysed and compared using X-ray diffraction technique. The biological activities of the obtained product were examined for antibacterial assessment against two bacterial strains that include two-gram negative strains (E.Coli and S. aureus). The nanostructured product found to exhibit excellent antibacterial agent against all the strains. Biosynthesised nanostructure showed its efficacy against A549 lung cancer cells which might attribute to a larger surface to volume ratio of nanorods like fibres. The authors observation suggest that CuS nanorods like fibres can significantly reduce the cell growth with IC50 value of 31.2 μg/ml.
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research

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This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, the obtained IC50 concentration of 51.25 μg/mL exhibits significant anticancer activity against A549 cells than other tested concentrations because of the release of zinc ions, which induce the cell apoptosis. Furthermore, studies on cell cycle validate that ZnO NPs arrest the cell cycle at the sub-G1 phase of A549 cells. These results suggest the utility of phytogenic ZnO NPs for various biomedical applications.Graphical abstract
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Abstract The synthesis of nickel oxide nanoparticles (NiO NPs) and graphene/nickel oxide nanocomposites (Gr/NiO NCs) was performed using a simple chemical reduction method. Powder X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were used to examine the crystalline nature and thermal stability of the synthesized NiO NPs and Gr/NiO NCs, respectively. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were utilized to observe the morphology of NiO NPs and Gr/NiO NCs and estimate their size range. TEM suggested that the NiO NPs were speared onto the surface of Gr nanosheet. The ...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Publication date: September 2019Source: Materials Science and Engineering: C, Volume 102Author(s): Govindan Rajivgandhi, Muthuchamy Maruthupandy, Franck Quero, Wen-Jun LiAbstractThe synthesis of nickel oxide nanoparticles (NiO NPs) and graphene/nickel oxide nanocomposites (Gr/NiO NCs) was performed using a simple chemical reduction method. Powder X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were used to examine the crystalline nature and thermal stability of the synthesized NiO NPs and Gr/NiO NCs, respectively. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were utilized to ob...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract New Pd(II) and Pt(IV) triazine complexes [Pt3(L 1 )2(Cl)9(H2O)3].3Cl.3H2O (1), [Pt3(L 2 )2(Cl)9(H2O)3].3Cl (2), [Pt3(L 3 )2(Cl)9(H2O)3].3Cl (3), [Pt2(L 4 )2(Cl)6(H2O)2] .2Cl.4H2O (4), [Pd3(L 1 )2(H2O)6] .3Cl2 (5), [Pd3(L 2 )2(H2O)6].3Cl2 (6), [Pd3(L 3 )2(H2O)6].3Cl2 (7), and [Pd2(L 4 )2(H2O)4].2Cl2 (8) were synthesized and well characterized using elemental analyses, molar conductance, IR, UV-Vis, magnetic susceptibility, 1H, 13C-NMR spectra, and thermal analyses. These analyses deduced that the L 1 , L 2 , and L 3 ligands act as tridentate forming octahedral geometry with Pt(IV) metal ions and square pla...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 12 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): K. Karthik, S. Dhanuskodi, C. Gobinath, S. Prabukumar, S. SivaramakrishnanAbstractMagnesium oxide (MgO) nanostructures were prepared using microwave-assisted (M 1) and hydrothermal (M 2) methods and characterized by XRD, SEM and FT-IR. It exhibits cubic structure with an average crystallite size of 20 nm (M 1) and 14 nm (M 2) and the lattice strain (WH plot) is 0.0017 (M 1), 0.0037 (M 2). It's spherical and rods like structures are confirmed through SEM and TEM. The vibrational stretching mode of M...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Publication date: Available online 21 March 2018 Source:Journal of Photochemistry and Photobiology B: Biology Author(s): P. Kganyago, L.M. Mahlaule-Glory, M.M. Mathipa, B. Ntsendwana, N. Mketo, Z. Mbita, N.C. Hintsho-Mbita NiO nanoparticles have emerged as ideal candidates in various fields due to their magnetic, electrical and optical properties. The coupling of plant extracts that have anticancer and antibacterial properties with NiO nanoparticles has increased their usage in the biomedical field. In this work, we report on the novel synthesis of NiO nanoparticles using a local medicinal plant, Monsonia burkenea. The ni...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Abstract The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. The antimicrobial activity of ZnO nanoparticles synthesized using the Ch. maju...
Source: Biomedical Microdevices - Category: Biomedical Engineering Authors: Tags: Biomed Microdevices Source Type: research
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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