Aberrant cortical ensembles and schizophrenia-like sensory phenotypes in setd1a mice.

A breakdown of synchrony within neuronal ensembles leading to destabilization of network “attractors” could be a defining aspect of neuropsychiatric diseases like schizophrenia (SZ), representing a common downstream convergence point for the diverse etiological pathways associated with the disease. Using a mouse genetic model, here we demonstrate how altered ensembles are associated with pathological sensory cortical processing phenotypes resulting from loss of function mutations in the setd1a gene, a recently identified rare risk genotype with very high penetrance for SZ.

Source: Biological Psychiatry - January 15, 2020 Category: Psychiatry Authors: Jordan P. Hamm, Yuriy Shymkiv, Jun Mukai, Joseph A. Gogos, Rafael Yuste Tags: Priority Communication Source Type: research