Study Shows Benefits of Long-Term Antipsychotic Use for Patients With Schizophrenia

Long-term antipsychotic use is associated with substantially decreased mortality compared with no antipsychotic use, especially among patients treated with clozapine, according to areport inWorld Psychiatry, the journal of the World Psychiatric Association.Moreover, long ‐term antipsychotic use does not increase the likelihood that a patient will experience severe illness leading to hospitalization, wrote Heidi Taipale, Ph.D., of the Karolinska Institute in Sweden and colleagues.People with schizophrenia have a shorter average life expectancy than the general population. Taipale and colleagues wanted to know if these differences may be partly due to adverse effects associated with antipsychotics, such as weight gain.They used data from a Finnish national registry on 62,250 patients treated for schizophrenia between 1972 and 2014. Specifically, they analyzed the association between periods of antipsychotic use and no antipsychotic use with hospitalization and/or death.Hospitalization was classified as either “somatic” hospitalization (all hospitalizations except psychiatric and cardiovascular hospitalizations) or “cardiovascular” hospitalization. Three causes of death were analyzed: all‐cause mortality, cardiovascular mortality, and suicide death.There was no increased risk of somatic or cardiovascular hospitalization associated with periods of antipsychotic use compared with periods of non-use. Cardiovascular deaths, suicide deaths, and all ‐caus...
Source: Psychiatr News - Category: Psychiatry Tags: antipsychotics death Heidi Taipale hospitalization long-term use schizophrenia side effects suicide World Psychiatry Source Type: research

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Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract OBJECTIVES: To evaluate the relationship between the mortality rates associated with psychiatric conditions like depression and schizophrenia compared with chronic medical conditions like hypertension and diabetes. METHODS: Examined clinical trial safety data from New Drug Approval programmes reviewed by the US Food and Drug Administration and calculated all-cause and suicide/non-suicide mortality rates per 100,000 patient-exposure-years (PEY) for seven diabetes, 12 hypertension, 11 depression, and nine schizophrenia programmes (126,151 patients, 63,106.3 PEY). RESULTS: Depression (894.8 ...
Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research
Dear Colleagues: Welcome to the July–August 2018 issue of Innovations in Clinical Neuroscience (ICNS). We start this issue with a report by Brennan et al titled, “Implementation of the Electronic Columbia-Suicide Severity Rating Scale (eCSSRS) Across Four Phase IIIb Clinical Trials in HIV-infected Individuals (ARIA, STRIIVING, DAWNING and INSPIRING).” Here, researchers assessed site perspectives on implementation of the eC-SSRS, which was used in Phase IIIb studies of dolutegravir. Next, in a case report by Teo et al titled, “Atypical Neuroleptic Malignant Syndrome (NMS) Precipitated by Clozapine an...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Editor's Message: Issue Highlights Editorial Message Source Type: research
This study focuses on whether hypertension, diabetes, hyperlipidemia and tobacco could be related to the reduced lifetime expectancy in patients with schizophrenia spectrum disorder.MethodsFrom the Clinical Long-term Investigation of Psychosis in Sweden (CLIPS) study, 79 patients now deceased were analyzed at baseline. Data regarding occurrence of hypertension, diabetes, hyperlipidemia, tobacco but also data on the type of antipsychotic treatment were collected. Two patients, one with zero risk factors and one with 5 risk factors were omitted from the study. We created four categories based on the number of risk factors. 3...
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research
We present a case of secondary adrenal insufficiency caused by a pituitary tumor. During the course of evaluation and treatment, the patient developed a psychotic episode. We will briefly review the condition of adrenal insufficiency and propose how hypocortisolemia can result in psychosis. Keywords: Psychosis, secondary adrenal insufficiency, hypocortisolemia, proinflammatory cytokines Innov Clin Neurosci. 2017;14(9–10):4–10 Incidentally found lesions of the pituitary gland, referred to as “pituitary incidentalomas,” are present in approximately 10 percent of individuals undergoing brain magnetic r...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue hypocortisolemia proinflammatory cytokines psychosis secondary adrenal insufficiency Source Type: research
In conclusion, CAVD is highly prevalent. Long understood as a passive process, it is now known to be complex and one which involves pathophysiological mechanisms similar to those of atherosclerosis. Understanding these mechanisms could help to establish new therapeutic targets that might allow us to halt or at least slow down the progression of the disease. Early Steps in the Tissue Engineering of Intervertebral Discs https://www.fightaging.org/archives/2017/08/early-steps-in-the-tissue-engineering-of-intervertebral-discs/ In this paper, researchers report on progress towards the manufacture of interver...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This article attempts to identify and put into perspective the different approaches that could globally prevent the suffering induced by schizophrenia, from the detection of early psychosis to the impact on individual and family functioning and emotional health. Schizophrenia causes, at the community level, a number of difficult consequences and associated costs, which likely could be reduced if specific strategies, already known and documented internationally, were applied. Two areas not explored in this article: the role of medication and the issue of suicide prevention. In the scope of screening and early treatment, gen...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
The objective of this study was to describe the frequency of psychiatric and medical conditions among a large, diverse, insured population of adults with autism in the United States. Participants were adult members of Kaiser Permanente Northern California enrolled from 2008 to 2012. Autism spectrum disorder cases (N = 1507) were adults with autism spectrum disorder diagnoses (International Classification of Diseases-9-Clinical Modification codes 299.0, 299.8, 299.9) recorded in medical records on at least two separate occasions. Controls (N = 15,070) were adults without any autism spectrum disorder diagnoses sampled at a 1...
Source: Autism - Category: Neurology Authors: Tags: Special Issue Articles Source Type: research
This study though should be helpful in bringing a much needed dose of autism realities to the  public understanding of autism disorders and the harsh realities that accompany them.The health status of adults on the autism spectrumLisa A Croen1Ousseny Zerbo1Yinge Qian1Maria L Massolo1Steve Rich2Stephen Sidney1Clarissa Kripke31Kaiser Permanente Northern California—Oakland, USA2Kaiser Permanente Northern California—Santa Rosa, USA3University of California, San Francisco, USALisa A Croen, Division of Research, Kaiser Permanente Northern California—Oakland, 2000 Broadway, Oakland, CA 94612, USA. Email:&nb...
Source: Facing Autism in New Brunswick - Category: Child Development Authors: Source Type: blogs
Publication date: May 2015 Source:The Lancet Psychiatry, Volume 2, Issue 5 Author(s): David C Henderson , Brenda Vincenzi , Nicolas V Andrea , Melissa Ulloa , Paul M Copeland Patients with schizophrenia have increased mortality and morbidity compared with the general population. These patients have a 20-year shorter lifespan than peers without schizophrenia, mainly due to premature cardiovascular disease, suicide, and cancer. Patients with severe mental illness are at increased risk for cardiovascular disease related to increased incidence of diabetes, hypertension, smoking, poor diet, obesity, dyslipidaemia, metabolic s...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
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