Blood glucose concentration control for type 1 diabetic patients: a multiple-model strategy

In this study, a multiple-model strategy is evaluated as an alternative closed-loop method for subcutaneous insulin delivery in type 1 diabetes. Non-linearities of the glucose–insulin regulatory system are considered by modelling the system around five different operating points. After conducting some identification experiments in the UVA/Padova metabolic simulator (accepted simulator by the US Food and Drug Administration (FDA)), five transfer functions are obtained for these operating points. Paying attention to some physiological facts, the control objectives such as the required settling time and permissible bounds of overshoots and undershoots are determined for any transfer functions. Then, five PID controllers are tuned to achieve these objectives and a bank of controllers is constructed. To cope with difficulties of the presence of delays in subcutaneous blood glucose (BG) measuring and in administration of insulin, a glucose-dependent setpoint is considered as the desired trajectory for the BG concentration. The performance of the obtained closed-loop glucose–insulin regulatory system is investigated on the in silico adult cohort of the UVA/Padova metabolic simulator. The obtained results show that the proposed multiple-model strategy leads to a closed-loop mechanism with limited hyperglycemia and no severe hypoglycemia.
Source: IET Systems Biology - Category: Biology Source Type: research

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ConclusionThere was a negative correlation between cost of care and glycemic control. Lower cost of care was associated with high burden of psychosocial illness and poor quality of life.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
CONCLUSIONS: There has been a marked reduction in microvascular complications in Waikato youth and young adults with type 1 diabetes, but the reasons for the reduction are not clear given there has been no significant improvements in glycaemic control. PMID: 32078599 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Conclusion: Changes in the choroid may occur before the development of diabetic retinopathy and seem to progress with increasing diabetes mellitus duration despite the absence of diabetic retinopathy and without associated retina thickening. Choroidal thickness could be valuable for screening in diabetic children.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Conclusion Applying diabetes treatment information from the National Health and Nutrition Examination Survey, as formulated in our treatment-based algorithm, may better identify type 1 and type 2 diabetes cases and thus prevent the specific biases imposed by conventional approaches which include the age of diabetes diagnosis as an initial criterion for diabetes type classification.
Source: Cardiovascular Endocrinology - Category: Cardiology Tags: Original Articles Source Type: research
Publication date: Available online 21 February 2020Source: Life SciencesAuthor(s): Yu-pu Liu, Shui-jin Shao, Hai-dong GuoAbstractDiabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the patholo...
Source: Life Sciences - Category: Biology Source Type: research
No abstract available
Source: Nursing - Category: Nursing Tags: Department: COMMUNITY CARE Source Type: research
Condition:   Type 1 Diabetes Intervention:   Sponsor:   Jannet Svensson Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Type1diabetes Intervention:   Behavioral: Residential camp Sponsor:   University of Texas Southwestern Medical Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Type 1 Diabetes Intervention:   Sponsor:   Jannet Svensson Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Type1diabetes Intervention:   Behavioral: Residential camp Sponsor:   University of Texas Southwestern Medical Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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