Hypoglycaemia-free artificial pancreas project

Driving blood glycaemia from hyperglycaemia to euglycaemia as fast as possible while avoiding hypoglycaemia is a major problem for decades for type-1 diabetes and is solved in this study. A control algorithm is designed that guaranties hypoglycaemia avoidance for the first time both from the theory of positive systems point of view and from the most pragmatic clinical practice. The solution consists of a state feedback control law that computes the required hyperglycaemia correction bolus in real-time to safely steer glycaemia to the target. A rigorous proof is given that shows that the control-law respects the positivity of the control and of the glucose concentration error: as a result, no hypoglycaemic episode occurs. The so-called hypo-free strategy control is tested with all the UVA/Padova T1DM simulator patients (i.e. ten adults, ten adolescents, and ten children) during a fasting-night scenario and in a hybrid closed-loop scenario including three meals. The theoretical results are assessed by the simulations on a large cohort of virtual patients and encourage clinical trials.
Source: IET Systems Biology - Category: Biology Source Type: research

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DISCUSSION: The results suggest that PSEDT-1 is a valid and reliable tool that, in addition to the scale values of the competence areas of diabetes self-management, medical management, and general self-assertion, also determines the scale value of autonomous self-regulation to assess diabetes-related self-efficacy. PMID: 32069510 [PubMed - as supplied by publisher]
Source: PPmP Psychotherapie Psychosomatik Medizinische Psychologie - Category: Psychiatry & Psychology Tags: Psychother Psychosom Med Psychol Source Type: research
Authors: Katsimardou A, Imprialos K, Stavropoulos K, Sachinidis A, Doumas M, Athyros VG Abstract Introduction: Type 1 diabetes mellitus (T1DM) is a chronic, autoimmune disease that is characterized by total absence of insulin production. Hypertension is a common comorbidity in T1DM with complex pathophysiology, while it is also a well-recognized risk factor for the development of cardiovascular disease (CVD), as well as other microvascular diabetic complications.Areas covered: The purpose of this review is to present the current definitions, epidemiological data and prevalence rates of hypertension in T1DM, as well...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
I recently wrote about my new type 1 diabetes diagnosis, the quest for affordable meds and supplies, and the subsequent financial savings found through transparent pricing outside of my insurance plan. I summarized that health care“coverage” is very expensive, whereas medical services may be found much more affordably. My next step was to establish […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Diabetes Primary Care Source Type: blogs
ConclusionThis study shows that many adults with T1D and T2D both need and want to talk with their diabetes health professionals about the emotional impact of diabetes. Those who were most willing to have this conversation were most in need of emotional support.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Diabetes Technology&Therapeutics,Volume 22, Issue S1, Page S-141-S-148, February 2020.
Source: Diabetes Technology and Therapeutics - Category: Endocrinology Authors: Source Type: research
This study aimed to assess the effects of insufficient GPR109a signalling via genetic deletion of GPR109a on the development of renal injury in diabetic nephropathy. Gpr109a-/- mice or their wildtype littermates (Gpr109a+/+) were rendered diabetic with streptozotocin (STZ). Mice received a control diet or an isocaloric high fiber diet (12.5% resistant starch) for 24 weeks and gastrointestinal permeability and renal injury were determined. Diabetes was associated with increased albuminuria, glomerulosclerosis and inflammation. In comparison, Gpr109a-/- mice with diabetes did not show an altered renal phenotype. Resistant st...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Diabetes Technology&Therapeutics,Volume 22, Issue S1, Page S-141-S-148, February 2020.
Source: Diabetes Technology - Category: Endocrinology Authors: Source Type: research
Condition:   Diabetes Mellitus, Type 1 Intervention:   Biological: teplizumab Sponsor:   Provention Bio, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Diabetes Mellitus, Type 1 Interventions:   Device: Medtronic Minimed 670G 3.0 HCL;   Device: Medtronic Minimed 670G 4.0 AHCL Sponsors:   Rabin Medical Center;   GIF;   Medtronic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Type 1 Diabetes Intervention:   Device: DreaMed Advisor Pro Sponsor:   Rabin Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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