The impact of culture conditions on blastocyst formation and aneuploidy rates: a comparison between single-step and sequential media in a large academic practice

ConclusionsOur study demonstrates an increase in aneuploidy in young women whose embryos were cultured in a single-step medium compared to sequential medium. This study highlights the importance of culture conditions on embryo ploidy and the need to stratify by patient age when examining the impact of culture conditions on overall cycle potential.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research

Related Links:

This study included 792 couples who underwent PGT-A after multiple pregnancy failures. Subgroup analyses were used to compare the blastocyst aneuploidy rate (BAR), implantation rate (IR), early miscarriage rate (EMR), and live birth rate (LBR). Multiple linear and logistic regression models were used to evaluate the associations. The control group comprised couples with ≤ 2 IFs, ≤ 1 BPL, ≤ 1 EM, and no LM.ResultsNotably, a history of ≥ 4 IFs was significantly associated with an increase in aneuploid blastocysts (42.86% vs. 33.05%,P = 0.044, B = 10.23 for 4...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Asim K. Duttaroy, Sanjay BasakAbstractFatty acids are essential for feto-placental growth and development. Maternal fatty acids and their metabolites are involved in every stage of pregnancy by supporting cell growth and development, cell signaling, and modulating other critical aspects of structural and functional processes. Early placentation process is critical for placental growth and function. Several fatty acids modulate angiogenesis as observed by increased tube formation and secretion of angio...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
AbstractThe aim of this study was to assess the role of  ultrasound in first the trimester of pregnancy for confirmation of pregnancy, number of fetuses, chorionicity, amnionicity if multiples, viability, assessment of gestational age, identification of structural anomalies and assessment of risk for chromosomal abnormalities. This was a prospective o bservational study. All pregnant women registered within 13+6 weeks were  offered a routine scan between 11+0 and 13+6 weeks. All scans were  done by obstetricians, fetal medicine specialists or radiologists are accredited by the Fetal Medic...
Source: Journal of Fetal Medicine - Category: Perinatology & Neonatology Source Type: research
AbstractSyphilis is a sexually transmitted bacterial disease relevant to pregnancy because it has the potential to cause congenital syphilis if it occurs at any time during pregnancy. An upsurge in cases of syphilis in women and hence congenital syphilis has been reported worldwide recently. 40% of cases can result in spontaneous miscarriages, stillbirth, non-immune hydrops, fetal growth restriction and perinatal death, as well as serious sequelae in liveborn infected children. Pregnancy complications can be avoided by early detection and treatment in the antenatal period. All antenatal women should be screened for syphili...
Source: Journal of Fetal Medicine - Category: Perinatology & Neonatology Source Type: research
CONCLUSIONS: The current evidence from randomised controlled trials does not support or refute the clinical use of intracytoplasmic sperm injection (intracytoplasmic morphologically selected sperm injection (IMSI). We are very uncertain of the chances of having a live birth and of the risk of having a miscarriage. We found very low-quality evidence that IMSI may increase chances of a clinical pregnancy, which means that we are still very uncertain about any real difference. We did not find any trials reporting on the risk of congenital abnormalities. Well-designed and sufficiently powered trials are still required. PM...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
(CNN) — Taking some common antibiotics during the first trimester of pregnancy was linked with higher risk of birth defects, according to a new study. The study, published Wednesday in the medical journal BMJ, found an increased risk of birth defects in the children of women who were prescribed macrolides during the first three months of pregnancy compared to mothers who were prescribed penicillin. Macrolide antibiotics include erythromycin, clarithromycin and azithromycin, and they are used to treat infections, such as pneumonia, bronchitis and urinary, skin and sexually transmitted diseases. They are often prescrib...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Source Type: news
In this study, we aimed to investigate the degree of mosaicism present in villi by a combination of three different methods, namely conventional karyotyping following culture, multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH), with a view to exploring the incidence of selective growth of mosaic CV cells during the process of culture for conventional karyotyping. CV samples were obtained from 207 patients with early spontaneous miscarriage (ESM). There were 56 (56/207, 27.1%) samples with mosaic chromosome detected by FISH based on four or five types of probes in this stud...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Asherman syndrome (AS) is an acquired condition defined by the presence of intrauterine adhesions (IUAs) that result when the bona fide endometrium is replaced by fibrotic tissues. IUAs provoke symptoms such as menstrual abnormalities, pelvic pain, recurrent miscarriage, infertility, abnormal placentation, and attendant psychological distress (1). The destruction of healthy endometrium arises from multiple factors that affect the endometrial stem cell niche and create IUAs. The most common is curettage of the pregnant uterus after delivery of miscarriage.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Fertile battle Source Type: research
Conclusions: Data highlight the importance of developing specific support groups, for primiparae, due to their great emotional vulnerability, and for women with past miscarriage, to help them cope in adaptive ways with a new pregnancy. PMID: 32064903 [PubMed - as supplied by publisher]
Source: Journal of Reproductive and Infant Psychology - Category: Psychiatry & Psychology Tags: J Reprod Infant Psychol Source Type: research
ConclusionsFIGO type 3 fibroid ≥30 mm or multiple fibroids might exert deleterious impact on implantation, clinical pregnancy and live birth rate of IVF cycles.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
More News: Academia | Genetics | Miscarriage | Pregnancy | Reproduction Medicine | Study | Women