Use of in vitro 3D tissue models in genotoxicity testing: strategic fit, validation status and way forward. Report of the working group from the 7th International workshop on genotoxicity testing (IWGT)

Publication date: Available online 15 January 2020Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Stefan Pfuhler, Jan van Benthem, Rodger Curren, Shareen Doak, Maria Dusinska, Makoto Hayashi, Robert H. Heflich, Darren Kidd, David Kirkland, Yang Luan, Gladys Ouedraogo, Kerstin Reisinger, Toshio Sofuni, Frédérique van Acker, Ying Yang, Raffaella CorviAbstractUse of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress has been made with establishing robust protocols for skin, airway (lung) and liver tissue equivalents. In light of these advancements, a “Use of 3D Tissues in Genotoxicity Testing” working group (WG) met at the 7th IWGT meeting in Tokyo, November 2017 to discuss progress with these models and how they may fit into a genotoxicity testing strategy. The workshop demonstrated that skin models have reached an advanced state of validation following over 10 years of development, while liver and airway model-based genotoxicity assays show promise but are at an early stage of development. Further effort in liver and airway model-based assays is needed to address the lack of coverage of the three main endpoints of genotoxicity (mutagenicity, clastogenicity and aneugenicity), and information on metabolic competence. The IWGT WG believes that the 3D skin co...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research

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