Radioembolization with 90 Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy

ConclusionRadioembolization after systemic radionuclide treatments is safe, and the occurrence of radioembolization-induced liver disease is rare.Level of Evidence4, case series.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research

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Conclusion: IRE1α was induced in PNALD cell model and suppression of IRE1α resulted in reduced steatosis in this cell disease model. Taken together, our data suggested that the IRE1α pathway may be involved in the development of PNALD.α signal in the process of PNALD. α signal in the process of PNALD. α signal in the process of PNALD. PMID: 32089676 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: Araujo LCC, Bordin S, Carvalho CRO Abstract The expression levels of some reference genes and proteins are used for data normalization and quantification. However, these levels can change in response to experimental conditions or treatments. Aim. The aim of this work was to evaluate reference gene and protein expression in models of nonalcoholic fatty liver disease, using mice fed with a high-fat diet (HFD) and mice that are genetically obese (ob/ob). Main Methods. Histological staining techniques were used to verify the morphology and quantify the amount of lipid droplets present in the liver. Real-time p...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Conclusions: PBT is clinically useful in patients with unresectable CC, even in the presence of large tumors or regional nodal metastases. Its use may induce durable symptom relief, without increasing acute or late toxicity.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
This article discusses current and potential future techniques to improve outcomes in these vulnerable patients.
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
Research increasingly shows that the gut-liver-brain axis is a crucial component in the pathophysiology of hepatic encephalopathy (HE). Due to the limitations of current standard-of-care medications, non-pharmacological treatments that target gut dysbiosis, including probiotics, nutritional management, and fecal microbiota transplants, are being considered as alternative and adjunct therapies. Meta-analyses note that probiotics could offer benefits in HE treatment, but have not shown superiority over lactulose. Emerging literature suggests that fecal microbiota transplants could offer a novel strategy to treat gut dysbiosi...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
Two-dimensional shear-wave elastography (2D-SWE) is an ultrasound-based technique used to stage liver fibrosis by measuring liver stiffness (LS). The diagnostic performance of 2D-SWE for assessing liver fibrosis in patients with primary biliary cholangitis (PBC) has not been reported before.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Liver, Pancreas and Biliary Tract Source Type: research
Celiac disease (CD) is common worldwide with increasing prevalence and changing presentation.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Alimentary Tract Source Type: research
We report the case of an 83-year-old woman presenting to the emergency department complaining of abdominal pain. The patient ’s previous medical history was significant for severe coronary artery disease, and acute cholecystitis treated conservatively due to cardiac comorbidity 5-years ago.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the month Source Type: research
Deaths in the United States due to alcohol consumption appear to be rising, according to areport in JAMA Network Open.“The rate of alcohol-induced deaths, largely due to alcoholic liver disease, increased substantially among men and women in the United States from 2000 to 2016, especially in more recent years,” wrote Susan Spillane, Ph.D., of the National Institutes of Health and colleagues.Spillane and colleagues analyzed data from the death certificates of U.S. residents (older than 15 years) who died between 2000 and 2016. The authors defined alcohol-induced deaths as those “due to alcohol consumption ...
Source: Psychiatr News - Category: Psychiatry Tags: Alaska Native alcohol alcohol-induced mortality American Indian death certificates deaths JAMA Network Open liver disease Susan Spillane Source Type: research
In this study, we evaluated the diagnostic value of serum Golgi protein 73 (GP73) for hepatic necroinflammatory damage in patients with NASH. Methods: The clinical data of 201 patients with NASH diagnosed by liver biopsy according to the Brunt staging system were collected retrospectively. The in situ expression of GP73 protein was measured by immunohistochemistry. The receiver operating characteristic (ROC) curve was used to calculate the area under the ROC curve (AUROC) of serum GP73 for diagnosing hepatic necroinflammatory damage. Results: The serum GP73 levels of NASH patients increased with the aggravation of ...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
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