Hepatic Arterial Bland Embolization Increases Th17 Cell Infiltration in a Syngeneic Rat Model of Hepatocellular Carcinoma

ConclusionTranscatheter hepatic arterial bland embolization induces local and systemic increased infiltration of Th17 cells and expression of their signature cytokine IL-17. In a simulated post-embolization environment, IL-17 significantly reduced McA-RH7777 cell migration.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research

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Publication date: 18 February 2020Source: Cell Reports, Volume 30, Issue 7Author(s): Lien Verboom, Arne Martens, Dario Priem, Esther Hoste, Mozes Sze, Hanna Vikkula, Lisette Van Hove, Sofie Voet, Jana Roels, Jonathan Maelfait, Laura Bongiovanni, Alain de Bruin, Charlotte L. Scott, Yvan Saeys, Manolis Pasparakis, Mathieu J.M. Bertrand, Geert van LooSummaryInflammatory signaling pathways are tightly regulated to avoid chronic inflammation and the development of disease. OTULIN is a deubiquitinating enzyme that controls inflammation by cleaving linear ubiquitin chains generated by the linear ubiquitin chain assembly complex. ...
Source: Cell Reports - Category: Cytology Source Type: research
Treatment of unresectable hepatocellular carcinoma (HCC) is complex, and there is limited consensus on the optimal nonsurgical management strategy. This is further complicated by new technologies and locoregional therapies (LRTs) that continue to evolve over time. Several medical specialists are involved in HCC diagnosis and treatment, and treatment strategies are often dictated by consulting physicians ’ specialties, rather than by evidence-based consensus. The most recent National Comprehensive Cancer Network Clinical Practice Guidelines recommend ablation approaches for tumors 5 cm in size (1).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Commentary Source Type: research
This article is the first to elucidate the relationship between METTL3 and glycometabolism in hepatocellular carcinoma, which provides new insight into the role of m6A ‐related genes in hepatocellular caricnoma. AbstractMETTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular carcinoma (HCC). We evaluated the expression and prognostic significance of METTL3 in 100 HCC cases and TCGA dataset. In HCC cases, both the RNA and protein expres...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionOur prognostic signature, which reflects the link between the immune microenvironment and HCC patient outcome, is promising for prognosis prediction in HCC.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
(Universit é de Gen è ve) Hepatocellular carcinoma, a liver cancer linked to the presence of fat in the liver, is one of the leading causes of cancer death worldwide. Scientists (UNIGE) have discovered a protein involved in the progression of a " fatty liver " towards cancer. This protein could allow early detection of the risk of developing liver cancer and open the way to new targeted therapies. These results highlight the close links between our diet and cancer development.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Contributors : Tomonori Matsumoto ; Hiroyuki MarusawaSeries Type : Expression profiling by arrayOrganism : Mus musculusHepatocellular carcinoma (HCC) generally arises in chronically inflamed liver and is thought to originate from regenerating liver cells that acquired genetic alterations. Both hepatocytes and ductular progenitor cells (DPCs) contribute to liver regeneration and are candidate cellular origins of HCCs. In the current study, we used lineage-tracing analysis to show that Epcam-expressing DPCs give rise to HCCs in inflamed liver. Under conditions in which proliferating DPCs differentiate into cholangiocytes but...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing i...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Ju Song Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells are two fundamental mediators of tumor progression, including hepatocellular carcinoma (HCC). Yet, the correlation between ECM stiffness and excessive aerobic glycolysis in promoting the development of HCC remains unknown. Here, we demonstrated that stiffer ECM promotes HCC cell migration depending on their accelerated aerobic glycolysis. Our results also indicated that stiffer ECM-induced YAP activation plays a major role in promoting aerobic glycolysis of HCC cells. Moreover, we showed that JNK and p38 MAPK signaling...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Oncogene, Published online: 19 February 2020; doi:10.1038/s41388-020-1215-6DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research
a El-Said The major risk factors for hepatocellular carcinoma (HCC) are hepatitis C and B viral infections that proceed to Chronic Liver Disease (CLD). Yet, the early diagnosis and treatment of HCC are challenging because the pathogenesis of HCC is not fully defined. To better understand the onset and development of HCC, untargeted GC-TOF MS metabolomics data were acquired from resected human HCC tissues and their paired non-tumor hepatic tissues (n = 46). Blood samples of the same HCC subjects (n = 23) were compared to CLD (n = 15) and healthy control (n = 15) blood samples. The participants were recruited from the...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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