Fear of Pain Driving Overtreatment

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Source: The Back Letter - Category: Orthopaedics Tags: Articles Source Type: research

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Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are well-established, but in populations with low back pain (LBP), there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to address this issue by identifying studies assessing conditioned pain modulation (CPM) and/or temporal summation of pain (TSP) in patients with LBP, comparing with either a healthy control group or using a method with reference data available. Qualitative sy...
Source: Pain - Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
Preventing and treating opioid dependence and withdrawal is a major clinical challenge, and the underlying mechanisms of opioid dependence and withdrawal remain elusive. We hypothesized that prolonged morphine exposure or chronic inflammation-induced μ-opioid receptor activity serves as a severe stress that elicits neuronal alterations and recapitulates events during development. Here, we report that Wnt signaling, which is important in developmental processes of the nervous system, plays a critical role in withdrawal symptoms from opioid receptor activation in mice. Repeated exposures of morphine or peripheral inflamma...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Central neuropathic pain (CNP) after spinal cord injury (SCI) is debilitating and immensely impacts the individual. Central neuropathic pain is relatively resistant to treatment administered after it develops, perhaps owing to irreversible pathological processes. Although preemptive treatment may overcome this shortcoming, its administration necessitates screening patients with clinically relevant biomarkers that could predict CNP early post-SCI. The aim was to search for such biomarkers by measuring pronociceptive and for the first time, antinociceptive indices early post-SCI. Participants were 47 patients with acute SCI ...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
The amygdala is a key subcortical region believed to contribute to emotional components of pain. As opioid receptors are found in both the central (CeA) and basolateral (BLA) nuclei of the amygdala, we investigated the effects of morphine microinjection on evoked pain responses, pain-motivated behaviors, dopamine release in the nucleus accumbens (NAc), and descending modulation in rats with left-side spinal nerve ligation (SNL). Morphine administered into the right or left CeA had no effect on nerve injury–induced tactile allodynia or mechanical hyperalgesia. Right, but not left, CeA morphine produced conditioned pla...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
We report a case of Anaplastic Large Cell Lymphoma mimicking a psoas abscess in a 6-year-old girl which posed significant diagnostic challenges. She presented with a vague two-month history of anaemia, fevers and back and abdominal pain. Axial imaging including MRI suggested a diffuse, inflammatory lesion in the right psoas muscle and she was commenced on an intravenous antibiotic therapy regimen but with little improvement. An open biopsy was performed and histology confirmed Anaplastic Lymphoma Kinase 1 positive ALCL. To our knowledge, this is only the second case of ALCL with the tissues adjacent the psoas muscle as the...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Spinal cord stimulation is an option for the management of chronic neuropathic pain, but is the pain relief obtained the result of a placebo effect?Pain
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
In conclusion, parents and coaches should be properly re-educated to help improve lower back, upper extremity, and shoulder pain among young basketball players. PMID: 32062615 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
I just read an interesting BBC article about why there are significantly more vegan women than men, which is mostly summarized by this statement at the top: When women hold two incompatible beliefs, they’re more likely to change their behaviour to reconcile them. Men, by comparison, tend to dig themselves in. The article cites a variety of studies that delve into gender differences and how these connect with dietary decisions. Reading it had an odd effect on me, making my vegan side feel good and my male side feel primitive and stupid. While I do consider myself an ethical vegan today, this article reminded ...
Source: Steve Pavlina's Personal Development Blog - Category: Psychiatry & Psychology Authors: Tags: Health Lifestyle Values Source Type: blogs
Conclusion: Both, the mTOR inhibitor everolimus as well as antiangiogenetic effects by the VEGFR inhibitor axitinib showed potential to prevent and retard formation of symptomatic spinal metastases. However, the therapeutic efficacy was only mild in this experimental model.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractBakker et al found a change in the magnetic resonance imaging (MRI) findings in 29 of 188 patients, when the examination was repeated at three months and at one year (1). The patients were all being investigated on account of back pain, with presumably varying degrees of concern about the possibility of inflammatory spondyloarthritis.Twelve (6.8%) patients were negative at the initial examination but became positive on subsequent testing. A percentage that was lower, but not dissimilar to Van Onna et al's report of 15% at two years (2).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
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