Schoolgirl, nine, beat bone cancer after doctors amputated and reattached her leg BACKWARDS

Amelia Eldred, nine, from Tamworth, Staffordshire, was diagnosed with osteosarcoma, a common type of bone cancer, in August 2017.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In conclusion, our study demonstrates that miR‐320a plays a critical role in osteosarcoma progression and may provide a potential therapeutic target for osteosarcoma.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionFindings from this study suggest that the SS-PU-SS-PEG micelles could achieve well-controlled triggered drug release in a reduction environment and could therefore improve the antitumor efficacy of osteosarcoma therapies.Translation potential of this articleIn this study we developed PEG-sheddable reduction-sensitive polyurethane micelles (SS-PU-SS-PEG), which were able to achieve well-controlled triggered release of anti-tumor drug Doxorubicin (DOX) in an intracellular reduction environment. DOX-loaded SS-PU-SS-PEG micelles markedly improved the antitumor efficacy in a Saos-2 cells-bearing xenograft tumor model....
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
-Fang Liu Osteosarcoma, the most common of all bone malignancies, has a high likelihood of lung metastasis. Up until now, the molecular mechanisms involved in osteosarcomas with lung metastases are not clearly understood. Recent observations have shown that the chemokine CXCL1 and its receptor CXCR2 assist with the homing of neutrophils into the tumor microenvironment. Here, we show that the CXCL1/CXCR2 paracrine axis is crucial for lung metastasis in osteosarcoma. In an in vivo lung metastasis model of osteosarcoma, lung blood vessels expressed CXCL1 and osteosarcoma cells expressed the CXCR2 receptor. CXCR2 expressio...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusion: In conjunction with the high levels of DJ-1 expression in osteosarcoma tissues and cell lines, the present results suggested that RA exhibited anticancer effects in osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway. Therefore, DJ-1 might be a biological target for RA in osteosarcoma cells.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
In conclusion, this study provides evidence that the oncolytic adenovirus Ad11 can enhance the effect of chemotherapy by inhibiting autophagy. The findings provide a cytological basis for the treatment of osteosarcoma with oncolytic adenovirus combined with cisplatin. PMID: 32051740 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Abstract Osteosarcoma is an aggressive bone cancer found in children and adolescents. The surgical removal of tumour and chemotherapy combined treatment for osteosarcoma has been widely accepted approach. However, the drug resistance developed by tumour cells resulted in recurrence of cancer. It is imperative to understand the molecular mechanism involved in the development of drug resistance and tumour progression for developing potential therapy. Tumour microenvironment and cellular cross talk via activation of various signalling pathways are responsible for tumour progression and metastasis. The comprehend revi...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research
In conclusion, we described for the first time laminopathic nuclear phenotypes in osteosarcoma cells, providing evidence for an altered lamins and emerin expression and a deregulated nucleoskeleton architecture of this tumor.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: 15 May 2020Source: Chemical Engineering Journal, Volume 388Author(s): Dejian Li, Tao Zhang, Chuwei Min, Hui Huang, Denghui Tan, Wenguang GuAbstractBenefit from the integration of therapeutic and diagnostic functions, theranostic nanoplatforms have attracted widespread attention in preclinical research. Herein, a biodegradable theranostics nanoplatform based on hollow mesoporous organosilica nanoparticles (HMONs) is designed for highly efficient photoacoustic (PA) imaging guided chemo-photothermal therapy (PTT) of human osteosarcoma cancer. In this design, HMONs with intrinsic tumor microenvironment-respon...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
ConclusionTLR4 activation by LPS increased CD8+ cells infiltrating into lung metastases and suppressed OS progression in the mouse model. TLR4 activation may suppress the progression of OS via stimulating CD8+ cells and can be expected as a novel treatment for OS.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
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