Avoiding complacency when treating uncontrolled seizures: why and how?
Avoiding complacency when treating uncontrolled seizures: why and how? Expert Rev Neurother. 2020 Jan 15;:1-9 Authors: Amin U, Benbadis SR Abstract Introduction: Despite the advances in the diagnosis and treatment of epilepsy, approximately 30% of the patients remain intractable. Uncontrolled seizures have deleterious consequences, including brain damage, cognitive decline, decreased quality of life, and increased mortality.Areas covered: In this article, the authors discuss the treatment gap in patients with intractable epilepsy and the possible mechanisms of drug resistance. The authors provide a treatment algorithm for patients with intractable epilepsy, including non-pharmacological treatment options, such as diet, neurostimulation (vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation), curative surgeries, and palliative surgeries.Expert opinion: There are currently several gaps in the management of seizures. Thirty percent of the 1% of the population with epilepsy is drug resistant. Non-pharmacologic treatments have improved in the last 30 years and continue to do so, but epilepsy surgery in general is still vastly under-utilized. Resective surgery is the only potentially curative procedure. Neurostimulation is generally palliative and is also improving, with smarter types of neurostimulation and paradigms. PMID: 31939686 [PubMed - as supplied by publisher]
For more information go tohttps://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 3/11/2020 12:00:00 PM
ConclusionsThe combination of rs-fMRI and EEG/iEEG can reveal more information about dynamic functional connectivity. However, simultaneous fMRI and EEG data acquisition present challenges. We have proposed system models for leveraging and processing independently acquired fMRI and EEG data.
Neural implants may provide treatment options for a wide variety of ailments, including Parkinson’s and epilepsy, but such devices have to work for long periods of time in a very difficult environment inside the cranium. One challenge is provid...
PURPOSE: The Japanese authorities require a 2-year seizure-free period for a driver's license in people with epilepsy. To evaluate the stringency of the criteria, we calculated the risk of fatal traffic crashes by epileptic seizure and compared that to the...
Discussion. An adequate interdisciplinary follow-up of children with CP requires a sensitization of clinicians to the complex topic of cognitive and academic problems in this population and a better synergy between the medical and educational worlds.
ConclusionThere were no differences for LCM outcomes between general and ID groups. Slower LCM titration in ID populations in the first 3 months was associated with higher retention and lower behavioural side effects as compared to similar European studies.
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(Michigan Medicine - University of Michigan) SCN8A encephalopathy, a rare form of childhood epilepsy, could be improved with a treatment already approved for other uses.
This study can serve as a proof of principle for the methodology, but a larger sample is needed to examine the differential effects of individual antiepileptic drugs.