White matter and cerebellar involvement in alternating hemiplegia of childhood

AbstractObjectiveTo determine whether brain volumetric and white matter microstructural changes are present and correlate with neurological impairment in subjects with alternating hemiplegia of childhood (AHC).MethodsIn this prospective single-center study, 12 AHC subjects (mean age 22.9  years) and 24 controls were studied with 3DT1-weighted MR imaging and high angular resolution diffusion imaging at 3T. Data obtained with voxel-based morphometry and tract-based spatial statistics were correlated with motor impairment using the International Cooperative Ataxia Rating Scale (ICARS) and Movement and Disability sub-scales of Burke-Fahn-Marsden Dystonia Rating Scale (BFMMS and BFMDS).ResultsCompared to healthy controls, AHC subjects showed lower total brain volume (P <  0.001) and white matter volume (P = 0.002), with reduced clusters of white matter in frontal and parietal regions (P <  0.001). No significant regional differences were found in cortical or subcortical grey matter volumes. Lower cerebellar subvolumes correlated with worse ataxic symptoms and global motor impairment in AHC group (P <  0.001). Increased mean and radial diffusivity values were found in the corpus callosum, corticospinal tracts, superior and inferior longitudinal fasciculi, subcortical frontotemporal white matter, internal and external capsules, and optic radiations (P <  0.001). These diffusion scalar changes correlated with higher ICARS and BFMDS scores (P < â€...
Source: Journal of Neurology - Category: Neurology Source Type: research