The synergistic triad between microcin, colibactin, and salmochelin gene clusters in uropathogenic Escherichia coli

Publication date: Available online 16 January 2020Source: Microbes and InfectionAuthor(s): Clémence Massip, Camille V. Chagneau, Michèle Boury, Eric OswaldAbstractA functional synergy was previously demonstrated between microcin, salmochelin and colibactin islands in Escherichia coli strains from B2 phylogroup. We aimed to determine this association prevalence in uropathogenic E. coli, and whether it was predictive of the infection severity in a collection of 225 E. coli strains from urinary samples. The high prevalence of this triad, even if it wasn't correlated with infection severity, suggested that it might not be a virulence factor per se within the urinary tract, but would promote its colonization. This triad would enable the strain to dominate the rectal reservoir with a minimal genetic cost.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research