Improving Engagement of Mild to Moderate Dementia Alzheimer's Disease Patients Using Evidence-Based Visual Cognitive Stimulation Exercises.

CONCLUSIONS: The type and characteristics of CS exercises have an impact on the engagement level of AD patients with mild to moderate dementia. Further studies are necessary to better understand which characteristics of the exercises affect the engagement of the patient according to their particularities. This kind of study may help the design of CS sessions and improve the results obtained. PMID: 31940610 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research

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Authors: Elahifasaee F, Li F, Yang M Abstract Magnetic resonance (MR) imaging is a widely used imaging modality for detection of brain anatomical variations caused by brain diseases such as Alzheimer's disease (AD) and mild cognitive impairment (MCI). AD considered as an irreversible neurodegenerative disorder with progressive memory impairment moreover cognitive functions, while MCI would be considered as a transitional phase amongst age-related cognitive weakening. Numerous machine learning approaches have been examined, aiming at AD computer-aided diagnosis through employing MR image analysis. Conversely, MR bra...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with polar lipids’ concentrates from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in ω3 long-chain polyunsaturated fatty ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
AbstractAlzheimer ’s disease (AD) is the most common cause of dementia worldwide. AD is a multifactorial disease with simultaneous occurrence of several connected pathological processes including mitochondrial dysfunction and impaired proteostasis. Most of these are also implicated in organismal aging per se. The p resence of separable pathological conditions poses the opportunity to try combination treatments that target these different processes separately. This approach may provide an effective strategy to target AD; therefore, we investigated whether a combination of metformin (targeting mitochondria and e nergy ...
Source: AGE - Category: Geriatrics Source Type: research
ConclusionsCustomized FreeSurfer-based brain atlas for DARTEL tool is easy to create and useful for the analysis of PET and MR images with high adaptability and reliability for broad research purposes.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
DISCUSSION: The estimates could help to inform patients, their families, and policymakers about probable trajectories. PMID: 32072728 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
AbstractSubcortical white matter ischemic lesions are increasingly recognized to have pathologic overlap in individuals with Alzheimer ’s disease (AD). The interaction of white matter ischemic lesions with amyloid pathology seen in AD is poorly characterized. We designed a novel mouse model of subcortical white matter ischemic stroke and AD that can inform our understanding of the cellular and molecular mechanisms of mixed vascul ar and AD dementia. Subcortical white matter ischemic stroke underlying forelimb motor cortex was induced by local stereotactic injection of an irreversible eNOS inhibitor. Subcortical white...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Abstract Objective: The aim of this descriptive study was to examine Appalachian stakeholder attitudes toward routine memory screening, and to compare and contrast results from a similar study conducted in an ethnically diverse rural Florida cohort. Determining perceptions about memory screening is essential prior to developing culturally relevant programs for increasing early dementia detection and management among rural underserved older adults at risk of cognitive impairment. Benefits of early detection include ruling out other causes of illness and treating accordingly, delaying onset of dementia symptoms thro...
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
Alzheimer’s disease (AD) is a common neurodegenerative disease, mainly manifested by cognitive dysfunction. It seriously reduces the quality of life, and there is no ideal treatment strategy in clinical practice. Clinical studies on the treatment of AD with Ginkgo biloba L. leaf extract (EGb) have been reported since 1980s, and many clinical studies have been carried out during the following 30 years. However, the benefits of EGb on the treatment of AD are still controversial. In this review, we collected the clinical trial reports of EGb on cognitive function from Pubmed, Elsevier, Europe PMC, and other database sin...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Testing for Alzheimer ’s disease and other forms of dementia is hardly foolproof, and could even backfire.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer ' s Disease Families and Family Life Memory Elderly Dementia Genetics and Heredity Anxiety and Stress Living Wills and Health Care Proxies Diet and Nutrition Depression (Mental) Frontotemporal Dementia Brain Nursing H Source Type: news
Research suggests that paying more attention to the “invisible disability” of hearing loss might improve our brains.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ears and Hearing Alzheimer ' s Disease Dementia Hearing Aids Brain Source Type: news
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