Safety and Efficacy of Combined Oral Contraceptive Ethinyl Estradiol/Drospirenone (YAZ) in Chinese Women: A Single-Arm, Open-Label, Multicenter, Post-Authorization Study
AbstractIntroductionThe study was conducted to assess the safety and efficacy of a combined oral contraceptive, YAZ, containing 3 mg drospirenone/20 μg ethinyl estradiol administered in a 24/4 regimen.MethodsThis was a single-arm, open-label, interventional, post-authorization safety surveillance study of YAZ across 6 treatment cycles. Primary objective was assessing its safety profile in Chinese women. Secondary objectives included assessing contraceptive efficacy, cycle control, and bleeding patterns among subjects with and without preceding abortion, along with efficacy in moderate acne vulgaris. Subgroup analyses included assessing efficacy in the dysmenorrhea group using a visual analog scale. All variables were analyzed by descriptive statistical methods.ResultsOf 1921 women treated with YAZ (mean age: 29.9 ± 5.5 years), 12.9% reported adverse drug reactions. Most frequently reported adverse events were nausea (2.6%), breast pain (2.3%), and breast swelling (1.3%). Unintended pregnancy rate (adjusted Pearl Index) was 0.3 (n = 2 pregnancies, 95% confidence interval 0.1–1.2). Incidence of overall withdrawal bleeding (cycle 2–cycle 5) was 93.3%–95.2%, of which 87.8%–95.1% in post-abortion subjects and 94.0%–95.3% in subjects without preceding abortion. Intra-cyclic bleeding (cycle 2–cycle 6) decreased in the overall population (from 14.9 to 5.5%), post-abortion subgroup (32...
Publication date: Available online 30 May 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Léa J. Becker, Sarah H. Journée, Pierre-Eric Lutz, Ipek Yalcin
Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Lijia Mai, Xiao Zhu, Fang Huang, Hongwen He, Wenguo Fan
Publication date: Available online 30 May 2020Source: Carbohydrate PolymersAuthor(s): Luana Heimfarth, Klécia Santos dos Anjos, Yasmim Maria Barbosa Gomes de Carvalho, Bruno Lucena dos Santos, Mairim Russo Serafini, Antônio Guilherme de Carvalho Neto, Paula Santos Nunes, José Ivo Araújo Beserra Filho, Sara Pereira da Silva, Alessandra Mussi Ribeiro, Daniel Pereira Bezerra, Ricardo Neves Marreto, Jullyana de Souza Siqueira Quintans, Adriano Antunes de Souza Araújo, Henrique Douglas Melo Coutinho, Marcus T. Scotti, Luciana Scotti, Lucindo José Quintans-Júnior
Publication date: Available online 31 May 2020Source: Chinese Journal of Chemical EngineeringAuthor(s): Guoju Yang, Ji Han, Yujun Huang, Xiaoxin Chen, Valentin Valtchev
Publication date: Available online 31 May 2020Source: Chinese Journal of Chemical EngineeringAuthor(s): Lichao Zhou, Gang Feng, Xiaojing Liu, Zhimiao Wang, Fang Li, Wei Xue, Yanji Wang
Publication date: Available online 30 May 2020Source: Chinese Journal of Chemical EngineeringAuthor(s): Muhammad Imran Kanjal, Majid Muneer, Amal Abdelhaleem, Wei Chu
Publication date: Available online 30 May 2020Source: Chinese Journal of Chemical EngineeringAuthor(s): Haoyu Zhai, Shaomeng Wang, Diankun Chen, Xuanying Cheng, Chuanxin Xie
Publication date: Available online 30 May 2020Source: Chinese Chemical LettersAuthor(s): Yao Liu, Jianfei Wei, Xiang Yan, Ming Zhao, Chaozhong Guo, Quan Xu
US sends Brazil 2m doses of hydroxychloroquine, despite safety fears;pressure builds on South African president. This blog is now closed please follow our continuing live coverage belowCoronavirus live coverage12.37amBSTWe are closing this blog now but you can stay up to date on all of our live coverage of the coronavirus pandemic at our new global blog below.https://www.theguardian.com/world/live/2020/jun/01/coronavirus-live-news-brazil-passes-500000-covid-19-cases-as-india-extends-lockdown-in-high-risk-zones12.10amBSTThat ’s all from me,Clea Skopeliti, for today. Many thanks to everyone who wrote in. I ’m han...
Ramachandran Gopinath, Sangineni K S Dhanalakshmi, Kiran Tejavath, Polapally VenuIndian Journal of Anaesthesia 2020 64(6):453-455