Structural and Functional Definition of Pulmonary Vein System in Chronic Hypoxia-induced Pulmonary Hypertension Rat Model.

In conclusion, our data provided fundamental data to comprehensively define the PV system in CHPH rat model. PMID: 31940248 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - Category: Cytology Authors: Tags: Am J Physiol Cell Physiol Source Type: research

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Publication date: May 2020Source: Biomedicine &Pharmacotherapy, Volume 125Author(s): Juan Li, Min Jia, Manling Liu, Zhi Cao, Xinju Wang, Na Feng, Xiaoming Gu, Shumiao Zhang, Rong Fan, Haitao Guo, Yuemin Wang, Mingchao Liu, Jianming PeiAbstractκ-opioid receptor (κ-OR) plays a key role in preventing hypoxic pulmonary hypertension (HPH) development after activated by exogenous agonist U50,488H. Calcium sensing receptor (CaSR) activation induces HPH by promoting vasoconstriction and vascular remodeling. The activated κ-OR is reported to inhibit the expression of CaSR in pulmonary artery smooth muscle cell...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
We report central invasive haemodynamic parameters at rest and exercise during a 3 year follow‐up after HTx in a sub‐study of the SCandiavian Heart transplant Everolimus De novo stUdy with earLy calcineurin inhibitor avoidancE trial. We hypothesized that the nephroprotective properties, the less development of cardiac allograft vasculopathy (CAV), and the antifibrotic properties of EVR, in comparison with CNI‐based immunosuppression, would demonstrate favourable invasive haemodynamic profiles in patients at rest and during exercise.Methods and resultsNinety of 115 HTx recipients randomized to EVR or CNI treatment per...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
DISCUSSION:  In patients with ESRD, PH is frequently associated with fluid retention as shown by bioimpedance spectroscopy. After adjustment of fluid to normal levels, PH was confirmed by invasive test in nearly 4 % of cases. PMID: 32053839 [PubMed - as supplied by publisher]
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Dear Editor,
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research
ConclusionThe obtained results confirm genotype ‒phenotype correlation in MSD, expand the spectrum of clinical presentation and are relevant for diagnosis including the extremely rare neonatal severe type of MSD.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
While aerobic exercise training (AET) has generally been shown to improve 6-min walk test (6MWT) distance (6MWD) in patients with pulmonary hypertension (PH), a substantial number of patients appear to adapt differently, with minimal or even negative changes in 6MWT distance being reported.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
ConclusionsVasodilator challenge with iNO is safe in advanced heart failure patients undergoing RHC prior to HT listing. It produces a reasonably predictable haemodynamic response, which occurs predominantly at the pulmonary circulation level. Clinical implications of iNO ‐induced reversibility may be relevant, but further systematic validation is warranted in larger cohorts.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
Persistent pulmonary hypertension of the newborn (PPHN) is characterized by sustained high levels of pulmonary vascular resistance after birth with etiology unclear; Arterial blood oxygen saturation of Tibetan...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
AbstractPurpose of reviewChronic thromboembolic pulmonary hypertension (CTEPH) is a major cause of precapillary pulmonary hypertension leading to right heart failure and death if left untreated. In addition to pulmonary endarterectomy, which is considered the standard of care, and specific drug therapy that is not however expected to offer relief from the mechanical component of the disease, the therapeutic options for CTEPH have expanded with the development of balloon pulmonary angioplasty (BPA). The purpose of this review is a better understanding and evaluation of BPA as a treatment option in CTEPH patients.Recent find...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Publication date: Available online 11 February 2020Source: Journal of Veterinary CardiologyAuthor(s): Takeshi Mizuno, Masashi Mizuno, Kayoko Harada, Hiroshi Takano, Asako Shinoda, Arane Takahashi, Kazuya Mamada, Kazuki Takamura, Ayaka Chen, Koji Iwanaga, Shin Ono, Masami UechiAbstractA 5-year-old male Toy Poodle was referred for corrective surgery of an atrial septal defect. A sinus venosus-type atrial septal defect (ASD) with partial anomalous venous connection, suspected pulmonary hypertension and pulmonary edema was confirmed by radiography, echocardiography, and cardiac computed tomography. Thoracic radiographs showed ...
Source: Journal of Veterinary Cardiology - Category: Veterinary Research Source Type: research
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