Prevalence of Iron Deficiency (ID) without Anemia in the General Population Presenting to Primary Care Clinics: A Cross-Sectional Study.
Prevalence of Iron Deficiency (ID) without Anemia in the General Population Presenting to Primary Care Clinics: A Cross-Sectional Study. Postgrad Med. 2020 Jan 14;: Authors: Abuaisha M, El Masri R, Itani H, Antoun J Abstract Objectives: There are no evidence-based recommendations to screen for iron deficiency in non-anemic patients, even though symptoms may be present. The aim of this study is to measure the prevalence of iron deficiency (ID) without anemia in the general population aged 18-50 presenting to primary care along with the incidence and time to develop anemia in the iron-deficient population.Methods: A single-center retrospective chart review of patients who presented to family medicine clinics between June 2010 and March 2018 at the American University of Beirut Medical Center (AUBMC). Adults 18-50 years old, who had a CBC and ferritin levels ordered with the proximity of maximum four weeks, with an absence of current or previously documented anemia (back to 2007) defined as MCV less than 80 or hemoglobin (Hb) less than 12 in females and 13 in males were included. ID was defined as serum ferritin level below 30 ng/mLResults: A total of 1,784 adults aged 18-50 years were included. The prevalence of iron deficiency without anemia was 57.5% (55.08% to 59.92%) among females and 7.6% (3.77% to 11.43%) among males. Iron deficiency without anemia was significantly associated with the level of hemoglobin (Hb) among females (chi-square, p
ConclusionsUnder a combination of leflunomide and methotrexate, liver toxicity and, for the first time, thrombotic microangiopathy occurred as side effects. Non-alcoholic fatty liver disease may have predisposed for the drug-induced liver toxicity.
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates its biological roles through a hexameric complex composed of IL-6 itself, its receptor IL-6R, and glycoprotein 130 (IL-6/IL-6R/gp130). This complex, in turn, activates different signaling mechanisms (classical and trans-signaling) to execute various biochemical functions. The trans-signaling mechanism activates various pathological routes, like JAK/STAT3, Ras/MAPK, PI3K-PKB/Akt, and regulation of CD4+ T cells and VEGF levels, which...
This study aimed to investigate the relationship of serum hemoglobin (HB) level with disease activity and structural damage in Chinese patients with rheumatoid arthritis (RA).MethodsA total of 890 RA patients and 890 normal subjects were enrolled in the case-control study. A HB threshold of
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CONCLUSION: Isoagglutinin-reduced Ig should have efficacy similar to nonreduced Ig and result in less IVIg-associated hemolysis. PMID: 31837028 [PubMed - as supplied by publisher]
Abstract BACKGROUND: The aim of this study was to evaluate the efficacy and safety of ferric carboxymaltose in rheumatic patients with iron deficiency anaemia. MATERIAL AND METHODS: The study retrospectively evaluated a cohort of 34 patients with iron deficiency anaemia affected by inflammatory rheumatic diseases that are refractory or intolerant to oral iron therapy. They were treated with ferric carboxymaltose for a total of 56 cycles of treatment. The primary end point was to evaluate the increase of haemoglobin after ferric carboxymaltose treatment. The secondary end point was safety, including the occurr...
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
Conclusions The long-term risks of autoimmune disorders are significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders show age- and sex-related clustering patterns.
A 58-year-old female patient was referred to our department with a one-year history of markedly elevated inflammatory markers and progressive anemia. Her chief complaint was a progressive weight loss of 14 kg within ten months accompanied by decreased appetite, as well as recurrent oral aphthous stomatitis, dyspnea on exertion and occasionally mild fevers up to 38.3 °C. She denied any diarrhea or current joint symptoms. Thirteen years ago, she was diagnosed with seronegative rheumatoid arthritis.
A 58-year-old female patient was referred to our department with a 1-year history of markedly elevated inflammatory markers and progressive anemia. Her chief complaint was a progressive weight loss of 14 kg within 10 months accompanied by decreased appetite, as well as recurrent oral aphthous stomatitis, dyspnea on exertion, and occasionally mild fevers up to 38.3 °C. She denied any diarrhea or current joint symptoms. Thirteen years ago, she was diagnosed with seronegative rheumatoid arthritis. Her past medical history was also significant for an episode of polyserositis.