Surface engineered nanoliposomal platform for selective lymphatic uptake of asenapine maleate: In vitro and in vivo studies

Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Renuka S. Managuli, Julie Tzu-Wen Wang, Farid Muhammad Faruqu, Abhjieet Pandey, Sanyog Jain, Khuloud T. Al-Jamal, Srinivas MutalikAbstractAsenapine maleate (ASPM) is an antipsychotic drug prescribed for the treatment of schizophrenia and bipolar disorder. ASPM possesses low oral bioavailability due to extensive hepatic metabolism. Therefore, RGD peptide conjugated liposomes loaded with ASPM were prepared to target Peyer's patches in the intestine which in-turn get access into intestinal lymphatic system thereby increasing the oral bioavailability of the drug. Liposomes were evaluated for size, zeta potential, differential scanning calorimetry (DSC), FTIR spectroscopy, X-ray diffraction (XRD), shape and morphology, in vitro drug release, cell line studies, everted intestinal uptake, pharmacodynamics, pharmacokinetics, tissue distribution, targetability and stability studies. In vitro drug release study showed the sustained release of drug from the formulations. Optimized liposomes (size
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research

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CONCLUSIONS: Our results support the presence of elevated FW at the onset of psychosis in both Sz and BD, which remains stable during the early course of the illness, with no evidence of either progression or remission. PMID: 31910929 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
What exactly is psychosis? What happens in the brain of a person with schizophrenia who is hallucinating? Schizophrenic Rachel Star Withers shares her personal hallucinations and delusions and Dr. Joseph Goldberg, who specializes in researching what goes on in the brain when someone is experiencing psychosis, joins to break down how the brain functions during psychotic episodes. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects in this episode of Inside Schizophrenia.  Highlights from “Psychosis in Schizophrenia” Episode [02:13]  Rachel, do...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
For more than a century, researchers have had a deeply-held belief that schizophrenia is one form of mental illness that has its basis in genetics. In the intervening years, hundreds of millions of person-hours and billions of dollars have been funneled pursuing the genetic theory of schizophrenia. Despite all of this enormous effort, researchers are starting to understand that perhaps the genetic component of schizophrenia has been overemphasized. And, in fact, the heritability estimates are not the 80-85 percent that some researchers claimed, but instead are far less. A new review article published in Psychiatry Researc...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Research Schizophrenia Causes Of Schizophrenia Schizophrenia Causes Source Type: blogs
Purpose of review To give an update on recent imaging studies probing positron emission tomography (PET) as a tool for improving biomarker-guided diagnosis of neuropsychiatric disorders. Recent findings Several studies confirmed the value of imaging of regional neuronal activity and imaging of dopaminergic, serotonergic, and other neuroreceptor function in the diagnostic process of neuropsychiatric disorders, particularly schizophrenia, depression/bipolar disorder, substance use disorders, obsessive compulsive disorders (OCD), and attention-deficit/hyperactivity disorder. Additionally, imaging brain microglial activat...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEUROIMAGING: Edited by Stefan Klöppel Source Type: research
Could the advancement of machine and deep learning algorithms be harnessed meaningfully in the area of mental health? Could depression, bipolar disorder, schizophrenia, or any other mental disorder be quantified so that technology could somehow add positively to their diagnostics or treatment? We tried to explore the uses of artificial intelligence in mental health care, and stumbled upon smart algorithms that support clinicians with early detection and diagnostics of mental health issues, with the flagging of suicide risks, and other ones that help patients manage their condition through counselling and constantly being t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine AI artificial intelligence bipolar disorder chatbots future of psychiatry mental disorder mental health mental health disorders mental health issues moodkit pacifica schizophrenia suicide thriveport woebot Source Type: blogs
Kanye West’s interview about living with bipolar disorder has recently made the media rounds. Mr. West speaks about not liking medication, about mania being a creative outlet, and the career edge he believes he has because of living with mental illness. Suffice to say, whenever someone gains an audience by speaking about living with bipolar disorder, our hosts are going to take notice. Do they agree with Mr. West? Listen now to find out. SUBSCRIBE &REVIEW “Do you know many homeless schizophrenics who are eating well?” – Gabe Howard   Highlights From ‘Kanye West Bipolar’...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Minding the Media Source Type: blogs
 While searching for a way past her own childhood sexual abuse, Rachel Grant learned that many people don’t understand what, exactly, sexual abuse is and how to recover. Using her counseling background, Rachel was able to research and learn valuable coping skills to improve her own life. Join us as Gabe and Rachel discuss the many factors involved in recovering from sexual trauma, steps society could take to reduce sexual abuse, and what the first step could be for others trying to get beyond surviving. SUBSCRIBE &REVIEW   Guest information for ‘Sexual Abuse Recovery’ Podcast Episode Rachel...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Podcast Recovery The Psych Central Show Trauma Source Type: blogs
Shervi Lie1†, Elise Rochet1†, Erik Segerdell2, Yuefang Ma1, Liam M. Ashander1, Audra M. A. Shadforth3,4, Timothy A. Blenkinsop5, Michael Z. Michael6, Binoy Appukuttan1,6, Beth Wilmot2 and Justine R. Smith1,6* 1Eye and Vision Health, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia 2Department of Biostatistics, Oregon Health and Sciences University, Portland, OR, United States 3Queensland Eye Institute, Brisbane, QLD, Australia 4School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia 5Departments of Cell, Developmental and Regener...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: It seems to be feasible to combine different types of clinical characteristics with biomarkers in order to detect bipolarity of all depressive episodes. Neurotrophic factors of our interest presented its stable discriminant potentiality in unipolar and bipolar depression, deserving validation analysis in larger samples.IntroductionThe Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) separates the mood disorders into two sections: depressive and related disorders, and bipolar and related disorders. The new version of the diagnostic manual of bipolar disorders emphasizes more specific ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Hui Xu1,2,3, Chenguang Guo1, Haining Li1, Lin Gao2, Ming Zhang1* and Yuan Wang1* 1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, China 3Faculty of Dentistry, University of Toronto, Toronto, ON, Canada Background and Purpose: Hemifacial spasm (HFS) is a rare neuromuscular disorder characterized by unilateral, involuntary, and paroxysmal contractions of orofacial muscles. To eluci...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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