1H-NMR metabolomics identifies significant changes in hypermetabolism after glutamine administration in burned rats.

In this study, 1H nuclear magnetic resonance spectroscopy (1H-NMR) was used to examine the effects of glutamine on plasma metabolites in burned rats and to explore the underlying mechanisms. After burn injury, the rats exhibited significant increases in resting energy expenditure (REE) and hypercatabolism, and anabolism was inhibited. The levels of metabolites that reflect the proteolysis of skeletal muscle, such as alanine, histidine, leucine, valine, 3-methylhistidine and creatine, were significantly increased. In addition, the burned rats exhibited energy synthesis dysfunction, as evidenced by a decrease in the ATP concentration and increased levels of lactic acid. Notably, the concentration of α-ketoisovalerate, which reflects the function of the mitochondrial membrane, was significantly increased, suggesting an impairment in mitochondrial function and inhibition of oxidative phosphorylation. Glutamine administration significantly alleviated post-burn hypermetabolism and inhibited proteolysis in skeletal muscle. Consequently, the levels of glutamine metabolites, such as glutamic acid and α-ketoglutarate, along with ATP synthesis were significantly increased, whereas alanine, leucine, 3-methylhistidine and lactic acid were significantly depleted. Furthermore, after glutamine administration, the synthesis of reductive compounds was increased, leading to significantly increased levels of reduced glutathione and NADPH. This process may be an important mechanism by...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research

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Basal cell carcinoma (BCC) is the most common skin cancer type in humans. Various factors play a role in BCC occurrence, but sunlight exposure is the most common etiologic factor. This case series presents three patients who had scarring after severe traumas (a deep abrasion, burn, and puncture injury); a long time after the respective traumatic events, a BCC occurred in the scar tissue. The lesions were excised, and BCCs were diagnosed based on histopathology. Although several etiologic factors may play a role in trauma-related BCC, the main mechanism remains unclear. A correct diagnosis with biopsy and an assessment of t...
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: ONLINE EXCLUSIVE Source Type: research
As I was trawling some motivational quotes the other day it struck me how many amazing ones there were that I was previously unaware of. So I thought it would be cool to collate the best for your perusal. Now, of course, I realize that you may well have heard of one or two, but I genuinely hadn’t (except one). So, please don’t give me a hard time or point out that you knew 18 out of 20 and thus I’m a philistine and deserve a damn good thrashing. 25 Great Motivational Quotes You’ve Never Heard Of 1. A successful man is one who can lay a firm foundation with the bricks others have thrown at him &...
Source: A Daring Adventure - Category: Psychiatry & Psychology Authors: Tags: Best Posts To Start With Source Type: blogs
Dear Candid Caregiver: My mom passed two years ago and my dad hasn’t done well since. Recently he had a stroke. My sister, who lives 1,000 miles away, came out for mom’s funeral, and she also visited for a few days after dad’s stroke, but she has a job and a family and couldn’t stay long. Now, dad’s been diagnosed with vascular dementia. Realistically, I’m the sole caregiver. I have two teenaged children, a husband who is, so far, supportive, and a job. I’m already beginning to feel burned out after just a few months. What can I do to help myself get through this and still take car...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jeffrey D. Einkauf, Jonathan D. Burns To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
CONCLUSIONS: This is consistent with our premise that WLI results in abnormal lung function and reflects small airways dysfunction and suggests that we may be able to provide a more sensitive tool for evaluation of WLI suspected cases. PMID: 32074359 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
(American Thoracic Society) Traditional stoves that burn biomass materials and are not properly ventilated, which are widely used in developing nations where cooking is done indoors, have been shown to significantly increase indoor levels of harmful PM2.5 (miniscule atmospheric particulates) and carbon monoxide (CO) and to stimulate biological processes that cause lung inflammation and may lead to chronic obstructive pulmonary disease (COPD), according to new research published online in the Annals of the American Thoracic Society.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionChinese herbal preparation HKSWF has remarkable curative effects on glomerulonephritis animals. HKSWF attenuates pyruvate dehydrogenase to improve glomerular injury.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 February 2020Source: BurnsAuthor(s): Tam N. Pham, Richard Goldstein, Gretchen J. Carrougher, Nicole S. Gibran, Jeremy Goverman, Peter C. Esselman, Lewis E. Kazis, Colleen M. Ryan, Jeffrey C. SchneiderAbstractIntroductionDespite many advances in burn care, the development of extremity contracture remains a common and vexing problem. Extremity contractures have been documented in up to one third of severely burned patients at discharge. However, little is known about the long-term impact of these contractures. The purpose of this study was to examine the association of extremity contract...
Source: Burns - Category: Dermatology Source Type: research
In this study the comparison of effects of alkaline pretreatment of sugarcane bagasse on anaerobic co-digestion of bagasse with cow dung is investigated. The Bagasse is pretreated with 2%(w/v) solution of NaOH and 2%(w/v) solution of Ca(OH)2 at room temperature for one day. Alkali pretreated bagasse is then mixed with cow dung in ratio1: 2 and the solid to water is mixed in ratio 1: 3. Then the biogas production from the slurry formed is observed at 35°C and 55°C. Results showed that biogas production is highest from NaOH treated Bagasse followed by Ca(OH)2 treatment and without treated bagasse at 35°C. Further...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
(NOVI SANZHARY, Ukraine) — Ukraine’s effort to quarantine more than 70 people evacuated from China over the new virus outbreak plunged into chaos Thursday as local residents opposing the move hurled stones at the evacuees and clashed with police. Officials deplored the violence and the country’s health minister pledged to share evacuees’ quarantine for two weeks in a bid to reassure protesters who fear they’ll be infected. Buses carrying evacuees were finally able to reach the designated place of quarantine after hours of clashes. The masked evacuees, exhausted by the long journey, were peekin...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 onetime Ukraine Source Type: news
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