RNA and protein-based nanodevices for mammalian post-transcriptional circuits.

RNA and protein-based nanodevices for mammalian post-transcriptional circuits. Curr Opin Biotechnol. 2020 Jan 11;63:99-110 Authors: Kawasaki S, Ono H, Hirosawa M, Saito H Abstract Mammalian synthetic gene circuits have promise in biological and medical research due to their capability of controlling cellular functions. Especially, post-transcriptional circuits are growing in interest because of features that include compatibility and superior safety. RNA-based molecular nanodevices are often a core component in these circuits. RNA nanodevices that act as translational controllers should be suitable for designing genetic circuits that execute complex functions. In this review, we introduce recent progress in designing synthetic RNA-based circuitry and building mammalian post-transcriptional networks. PMID: 31935668 [PubMed - as supplied by publisher]
Source: Current Opinion in Biotechnology - Category: Biotechnology Authors: Tags: Curr Opin Biotechnol Source Type: research