Evaluating the effects of oseltamivir phosphate on platelet counts: a retrospective review.

Evaluating the effects of oseltamivir phosphate on platelet counts: a retrospective review. Platelets. 2020 Jan 13;:1-5 Authors: Shaim H, McCaffrey P, Trieu JA, DeAnda A, Yates SG Abstract Desialylation of platelets results in platelet clearance by the Ashwell-Morrell Receptors (AMR) found on hepatocytes. Studies suggest that oseltamivir phosphate inhibits human sialidases, enzymes responsible for desialylation, extending the lifespan of circulating platelets. We thus evaluated, the effects of oseltamivir on platelet count (PC) following treatment. Of the 385 patients evaluated for influenza, 283 (73.5%) were influenza-infected. Of the 283 infected patients, 241 (85.2%) received oseltamivir (I + O+) while 42 patients did not (I + O-). One hundred two non-infected patients received oseltamivir (I-O+). The two groups receiving oseltamivir (I + O+, I-O+), demonstrated a statistically greater increase in the PC (57.53 ± 93.81, p = .013 and 50.79 ± 70.59, p = .023, respectively) relative to the group that did not (18.45 ± 89.33 × 109/L). The observed increase in PC was statistically similar (p = .61) in both groups receiving oseltamivir (I + O+, I-O+), suggesting that this effect is independent of influenza. Comparing clinical characteristics between responders and non-responders to oseltamivir treatment showed that only duration of oseltam...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research

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In this study, we report that analysis of the existing dataset transcriptome of blood immune cells of patients with influenza A virus (IAV) infection and after recovery (GSE108807) identified a novel lncRNA, termed as IVRPIE (Inhibiting IAVReplication by Promoting IFN and ISGs Expression), was involved in antiviral innate immunity. In vitro studies showed that IVRPIE was significantly upregulated in A549 cells after IAV infection. Gain-and-loss of function experiments displayed that enforced IVRPIE expression significantly inhibited IAV replication in A549 cells. Conversely, silencing IVRPIE promoted IAV replication. Furth...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
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Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Publication date: Available online 19 February 2020Source: Artificial Intelligence in MedicineAuthor(s): Fernando Jiménez, José Palma, Gracia Sánchez, David Marín, Francisco Palacios, M.D, Lucía López, M.DAbstractAntimicrobial resistance has become one of the most important health problems and global action plans have been proposed globally. Prevention plays a key role in these actions plan and, in this context, we propose the use of Artificial Intelligence, specifically Time Series Forecasting techniques, for predicting future outbreaks of Methicilin-resistant Staphylococcus aereu...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
The emergence of human infection with avian influenza A(H7N9) virus was reported in Wenshan City, southwestern China in 2017. The study describes the epidemiological and virological features of the outbreak an...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Viruses, Vol. 12, Pages 232: Characterization of Experimental Oro-Nasal Inoculation of Seba’s Short-Tailed Bats (Carollia perspicillata) with Bat Influenza A Virus H18N11 Viruses doi: 10.3390/v12020232 Authors: Gorka Schinköthe Ulrich Ciminski Schwemmle Beer Hoffmann In 2012 and 2013, the genomic sequences of two novel influenza A virus (IAV) subtypes, designated H17N10 and H18N11, were identified via next-generation sequencing in the feces of the little yellow-shouldered fruit bat (Sturnira lilium) and the flat-faced fruit-eating bat (Artibeus planirostris), respectively. The pathogen...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
The President has proposed a $38.7 billion budget for the National Institutes of Health in fiscal year (FY) 2021. This translates to a $3 billion or 7 percent cut in the agency’s funding compared to FY 2020. The NIH budget request includes a $50 million initiative to use artificial intelligence (AI) to develop a better understanding of the causes of chronic diseases and to identify early treatments. This plan is in line with the Administration’s “Industries of the Future” effort, which supports using and developing AI across sectors. The budget would provide $50 million for the Childhood Cancer ...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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