The Significance of α-Synuclein, Amyloid-β and Tau Pathologies in Parkinson's Disease Progression and Related Dementia.

Conclusion: The shared relevance of these pathologies in PD progression and dementia is in line with experimental data suggesting synergism between α-synuclein, tau and Aβ and with studies testing these proteins as disease biomarkers, hence favouring the eventual testing of therapeutic strategies targeting these proteins in PD. © 2013 S. Karger AG, Basel. PMID: 24028925 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24028925?dopt=Abstract

Source: Neuro-Degenerative Diseases - September 11, 2013 Category: Neurology Authors: Compta Y, Parkkinen L, Kempster P, Selikhova M, Lashley T, Holton JL, Lees AJ, Revesz T Tags: Neurodegener Dis Source Type: research