Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728.

Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728.
Nat Prod Res. 2020 Jan 14;:1-6
Authors: Saepua S, Kornsakulkarn J, Auncharoen P, Rachtawee P, Kongthong S, Boonyuen N, Harding DJ, Nehira T, Thongpanchang T, Thongpanchang C
Abstract
Five new compounds, iranginins A-E (1-5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher's method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).
PMID: 31933382 [PubMed - as supplied by publisher]

Source: Natural Product Research - January 13, 2020 Category: Biochemistry Authors: Saepua S, Kornsakulkarn J, Auncharoen P, Rachtawee P, Kongthong S, Boonyuen N, Harding DJ, Nehira T, Thongpanchang T, Thongpanchang C Tags: Nat Prod Res Source Type: research