Activation of mTORC2 Boosts Autophagy and Improves Cardiac Function in Old Flies

The activities of mTOR are well researched, given that mTOR inhibition slows aging in a number of species. This is one of the more prominent areas of research and development to emerge from the study of beneficial stress responses such as that produced by the practice of calorie restriction. The mTOR protein participates in cellular metabolism through a pair of protein complexes, and much of the work to date has focused on the protein complex mTORC1 rather than mTORC2. The present consensus (though not unchallenged) is that general inhibition of mTOR, such as via the use of rapamycin, is problematic because harmful effects arise from inhibition of mTORC2, offsetting the benefits due to inhibition of mTORC1. Certainly, it is the case that inhibiting mTORC2 alone shortens lifespan in laboratory animals, while inhibiting mTORC1 alone slows aging and extends life. Thus the development of drugs based on this research has focused on specific inhibition of mTORC1; several companies have a pipeline of small molecule therapies in later stage trials. Researchers here show that increased mTORC2 activity boosts autophagy and improves cardiac function in middle-aged flies, suggesting that the current industry of mTORC1 inhibition will soon enough be joined by an industry of mTORC2 upregulation. I remain unconvinced that the effect sizes in humans resulting from upregulated autophagy will be large enough to merit the strong focus placed on this line of research and developmen...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

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Source: BMJ Comments - Category: General Medicine Source Type: forums
BEST supplements for the heart: One of the gravest threats to life expectancy is heart disease so taking steps to protect your heart could mean the difference between life or death. Taking supplements for your heart has been met with a degree of scepticism over the years due to scant evidence, but recent research suggests a particular supplement may hold promise as a form of protection against heart disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 15 February 2020Source: Canadian Journal of CardiologyAuthor(s): Jenna Ashkanase, Nassr Nama, Ryan Vimukthie Sandarage, Joshua Penslar, Ronish Gupta, Sophia Ly, Melissa Wan, Phillip Tsang, Alex Nantsios, Erik Jacques, Hsin Yun Yang, Conrad Ian Tsang, Hajra Mazhar, Gang Xu, Maria Rodriguez, Samantha Gerber, Laurie M. Laird, Margaret Sampson, Derek T. Wong, James D. McNallyAbstractCardiac disease in children is associated with significant morbidity and mortality as well as increased health resource utilization. There is a perception that there is a paucity of high-quality studies, particula...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
A HEART attack can be a deadly occurrence. Coronary heart disease is the leading cause of it, and there's a noticeable symptom just on your fingernails that could indicate you have the disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Abstract Heart disease (especially myocardial infarction (MI)) and cancer are major causes of death. Recently, aptasensors with the applying of different nanostructures have been able to provide new windows for the early and inexpensive detection of these deadly diseases. Early, inexpensive, and accurate diagnosis by portable devices, especially aptasensors can increase the likelihood of survival as well as significantly reduce the cost of treatment. In this review, recent studies based on the designed aptasensors for the diagnosis of these diseases were collected, ordered, and reviewed. The biomarkers for the dia...
Source: Biosensors and Bioelectronics - Category: Biotechnology Authors: Tags: Biosens Bioelectron Source Type: research
AbstractCranial ultrasound on neonatal intensive care units is generally performed by intensive care physicians, but radiologists often provide this crucial bedside test to children on specialist paediatric cardiac intensive care units. On a paediatric cardiac intensive care unit, complex congenital cardiac conditions are commonly encountered in both pre- and postoperative scenarios, often with the use of extracorporeal membrane oxygenation (ECMO), which both increases the risks of a number of neurologic complications and results in significant changes in vascular physiology. The aim of this pictorial essay is to discuss c...
Source: Pediatric Radiology - Category: Radiology Source Type: research
AbstractPurpose of ReviewCongenital heart disease (CHD), the most common of birth defects, can be serious enough to require a lifetime of medical care including multiple surgeries or other interventions.Recent FindingsAdvances in ultrasound technology and a better understanding of the progression of CHDs have made it possible to intervenein utero. This early-stage intervention allows the still plastic cardiovascular system to return to a more normal trajectory thus sparing the newborn from negative consequences to morbidity and mortality.SummaryFetal cardiac intervention (FCI) has been successful altering the course of rig...
Source: Current Pediatrics Reports - Category: Pediatrics Source Type: research
Abstract This cross-sectional study assessed distribution and pattern of echocardiography confirmed congenital heart disease, among 593 pediatric patients in outpatient departments of a tertiary care hospital in eastern India. Commonest defects were ventricular septal defect (43, 40.7%), atrial septal defect (241, 31.7%), and tetralogy of Fallot (125, 21%). PMID: 32060246 [PubMed - in process]
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
ri S, Manohar K, Marwah A, Mishra S, Mohanty SR, Murthy KS, Suresh PV, Radhakrishnan S, Rajashekar P, Ramakrishnan S, Rao N, Rao SG, Reddy CH, Sharma R, Shivaprakasha K, Subramanyan R, Kumar RS, Talwar S, Tomar M, Verma S, Raju V, Working group on Management of Congenital Heart Disease in India Abstract JUSTIFICATION: A number of guidelines are available for management of congenital heart diseases from infancy to adult life. However, these guidelines are for patients living in high income countries. Separate guidelines, applicable to Indian children, are required when recommending an intervention for congenital he...
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
CONCLUSIONS: The prevalence of CHD in China may have ethnic differences. PMID: 32060241 [PubMed - in process]
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
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