The Renin-Angiotensin System in Huntington's disease: Villain or hero?

The Renin-Angiotensin System in Huntington's disease: Villain or hero?
Protein Pept Lett. 2020 Jan 10;:
Authors: Machado TCG, Guatimosim C, Kangussu LM
Abstract
Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder characterized by severe symptoms, including motor impairment, cognitive decline, and psychiatric alterations. Several systems, molecules, and mediators have been associated with the pathophysiology of HD. Among these, there is the Renin-Angiotensin System (RAS), a peptide hormone system that has been associated with the pathology of neuropsychiatric and neurodegenerative disorders. Important alterations in this system have been demonstrated in HD. However, the role of RAS components in HD is still unclear and needs further investigation. Nonetheless, modulation of the RAS components may represent a potential therapeutic strategy for the treatment of HD.
PMID: 31933441 [PubMed - as supplied by publisher]

Source: Protein and Peptide Letters - January 9, 2020 Category: Biochemistry Authors: Machado TCG, Guatimosim C, Kangussu LM Tags: Protein Pept Lett Source Type: research