Percept PC Deep Brain Neurostimulator with BrainSense Cleared in Europe

Medtronic obtained the European CE Mark for its Percept PC neurostimulator that uses smart feedback technology to deliver deep brain stimulation to treat Parkinson’s and other neurologic diseases. The so-called BrainSense technology powe...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Neurosurgery Source Type: blogs

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AbstractThe brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during Parkinson ’s disease (PD), which correlates with axial motor deficits. PPN-deep brain stimulation (DBS) can alleviate certain symptoms, but its mechanism(s) of action remains unknown. We previously characterized rats hemi-intranigrally injected with the proteasomal inhibitor lactacystin, as an accurate prec linical model of PD. Here we used a combination of chemogenetics with positron emission tomography imaging forin vivo interrogation of discrete neural networks in thi...
Source: Neurotherapeutics - Category: Neurology Source Type: research
AbstractNeuroimaging has seen a paradigm shift away from a formal description of local activity patterns towards studying distributed brain networks. The recently defined framework of the ‘human connectome’ enables global analysis of parts of the brain and their interconnections. Deep brain stimulation (DBS) is an invasive therapy for patients with severe movement disorders aiming to retune abnormal brain network activity by local high frequency stimulation of the basal ganglia. Beyond clinical utility, DBS represents a powerful research platform to study functional connectomics and the modulation of distribute...
Source: Brain - Category: Neurology Source Type: research
Conclusions The treatment used for PD, particularly DA, is associated with the development of ICDs and related behaviors. Susceptibility to these disorders depends on the associated risk factors. ICDs can have serious personal, family, psychosocial, financial, and medical consequences. However, in contrast, artistic activities have been described in patients with PD while undergoing treatment with DA. These patients are compulsive but report a positive influence on quality of life. These findings highlight the need for a very critical approach at the moment of Dopaminergic Replacement therapy choice. Author Contributio...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS.
Source: Clinics - Category: General Medicine Source Type: research
The objective of the present study was to elucidate the effects of STN DBS in PD on the dopamine system and neural circuitry. High-resolution positron emission tomography imaging of the vesicular monoamine transporter (VMAT2) and cerebral glucose metabolism were performed prior to DBS surgery and after 4 –6 months of STN stimulation.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
This study shows the validity of the presented asleep DBS procedure using robot assistance and intraoperative CT verification for accurate electrode placement with shorter operating room times. PMID: 30796551 [PubMed - as supplied by publisher]
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Ann Biomed Eng Source Type: research
Boston Scientific is releasing its Vercise Primary Cell (PC) and Vercise Gevia deep brain stimulation (DBS) systems in the U.S. Both have received recent FDA approval to be used in managing symptoms of Parkinson’s, as well as European regu...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Neurosurgery Rehab Source Type: blogs
Conclusion: We found a small but significant difference in the coordinates calculated on four different devices. These results have to be considered when performing studies comparing active contact locations or when following patients with an implanted DBS lead.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research
ConclusionThe clinicians should carefully evaluate the non ‐motor symptoms and life quality in those patients at relatively earlier stages and with lower medicine dosage to get more successful DBS outcomes.This article is protected by copyright. All rights reserved.
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: Original Article Source Type: research
ConclusionsPeri ‐electrode edema is a common, transient reaction to DBS lead placement and a convincing relation between edema and post‐operative clinical status is lacking.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
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