Antifungal effects of statins

In this study, we reviewed in-vitro and in-vivo studies, as well as clinical reports pertaining to the antifungal efficacy of statins. In addition, we have addressed various modulators of statin anti-fungal activity and the potential mechanisms responsible for their anti-fungal effects. In general, statins do possess anti-fungal activity, targeting a broad spectrum of fungal organisms including human opportunistic pathogens such as Candida spp. and Zygomycetes, Dermatophytes, alimentary toxigenic species such as Aspergillus spp., and fungi found in device implants such as Saccharomyces cerevisiae. Statins have been shown to augment a number of antifungal drug classes, for example, the azoles and polyenes. Synthetic statins are generally considered more potent than the first generation of fungal metabolites. Fluvastatin is considered the most effective statin with the broadest and most potent fungal inhibitory activity, including fungicidal and/or fungistatic properties. This has been demonstrated with plasma concentrations that can easily be achieved in a clinical setting. Additionally, statins can potentiate the efficacy of available antifungal drugs in a synergistic fashion. Although only a limited number of animal and human studies have been reported to date, observational cohort studies have confirmed that patients using statins have a reduced risk of candidemia-related complications. Further studies are warranted to confirm our findings and expand current knowledge of th...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research

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In this study, we first analyzed the chemical compounds of AG by HPLC-DAD-ESI-IT-TOF-MS n . Of the 31 compounds detected, 29 were identified based on previous results. Then, the effects of DMY and AG on high-fat diet hamster livers were studied and the metabolite levels and metabolic pathway activity of the liver were explored by 1H NMR metabolomics. Compared to the high-fat diet group, supplementation of AG and DMY attenuated the high-fat-induced increase in body weight, liver lipid deposition, serum triglycerides and total cholesterol levels, and normalized endogenous metabolite concentrations. PCA and PLS-DA score plots...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusion: The study shows that the metabolomic method may be a valuable tool for studying the essence of toxicity induced by traditional Chinese medicine. PMID: 32071608 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: May 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 189Author(s): Shima Rahim Pouran, Abolfazl Bayrami, Farid Mohammadi Arvanag, Aziz Habibi-Yangjeh, Reza Darvishi Cheshmeh Soltani, Ramesh Singh, Abdul Aziz Abdul Raman, Keun Hwa Chae, Alireza Khataee, Hee Kyoung KangAbstractIn this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. ...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 19 February 2020Source: Journal of Electroanalytical ChemistryAuthor(s): Bruna Coldibeli, Natalia Sayuri Matunaga Campos, Carlos Alberto Rossi Salamanca-Neto, Jessica Scremin, Gabriel Junquetti Mattos, Gustavo Galo Marcheafave, Elen Romão SartoriAbstractIn this work, we explored the efficiency of the use of the pretreated boron-doped diamond electrode (BDDE) coupled to electroanalytical techniques for the individual determination of pravastatin (PRAV) and its association with acetylsalicylic acid (ASA). The voltammetric behavior of PRAV and ASA was investigated by cyclic voltammetr...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Had a weird case a couple of weeks ago. My partner, who is an outstanding technical surgeon for implants (one of the best I have seen) had a stim follow up while he was on vacation. The wounds were dehiscing and the incisions looked odd (my partner has had only two infections over a 25 year career, so he is pretty damn good). I took her to the OR and removed the stim, packing the incisions open. Initial cultures were negative, but eventually grew candida. This patient was a diabetic with a... candida fungal infection with stimulator
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Conclusion Lactobacillus pentosus was the predominant species found at industrial scale in Spanish table olives biofilms, albeit certain genotypes of L. plantarum were also detected. At genotype level, biodiversity was higher in the Spanish-style table olive biofilms than in those of directly brined olives. The multivariate analysis based on technological and probiotic data showed that the main 16 genotypes obtained could be clustered in 3 great phenotypes, with some strains with potential application as multifunctional starters (especially L. pentosus Lp13 and LpG1 genotypes). Data obtained in the present study showed th...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, this Research Topic includes a wide range of interdisciplinary research work contributing to the ultimate goals of augmenting the existing knowledge and fostering the scientific field of ethnopharmacology in Central and Eastern Europe, as well as globally. This research topic successfully gathered comprehensive interdisciplinary information in the field of ethnopharmacology from the field surveys to standardization and elucidation of molecular mechanisms of action of natural products. Moreover, with consideration of the existing challenges in the field of drug discovery form medicinal plants, this research t...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
The cholesterol-lowering agents known as statins have in vitro activities against human pathogenic fungi, such as Candida species, Cryptococcus neoformans, and Zygomycetes. Synergy between statins and azoles against these fungi has also been reported. We evaluated the in vitro activities of two statins, lovastatin andsimvastatin, alone and in combination with azoles and amphotericin B, against clinical isolates ofAspergillus spp.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins,simvastatin and atorvastatin, on five Candida species andAspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Abstract Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes. In vitro studies suggest minimal interaction with recombinant cytochrome P450 enzymes (IC50 values>10 μM). Similar to...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
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