Cancers, Vol. 12, Pages 216: Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer
Cancers, Vol. 12, Pages 216: Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer
Cancers doi: 10.3390/cancers12010216
Authors:
Olga S. Kolovskaya
Tatiana N. Zamay
Galina S. Zamay
Vasily A. Babkin
Elena N. Medvedeva
Nadezhda A. Neverova
Andrey K. Kirichenko
Sergey S. Zamay
Ivan N. Lapin
Evgeny V. Morozov
Alexey E. Sokolov
Andrey A. Narodov
Dmitri G. Fedorov
Felix N. Tomilin
Vladimir N. Zabluda
Yulia Alekhina
Kirill A. Lukyanenko
Yury E. Glazyrin
Valery A. Svetlichnyi
Maxim V. Berezovski
Anna S. Kichkailo
Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magne...
Source: Cancers - Category: Cancer & Oncology Authors: Olga S. Kolovskaya Tatiana N. Zamay Galina S. Zamay Vasily A. Babkin Elena N. Medvedeva Nadezhda A. Neverova Andrey K. Kirichenko Sergey S. Zamay Ivan N. Lapin Evgeny V. Morozov Alexey E. Sokolov Andrey A. Narodov Dmitri G. Fedorov Felix N. Tomilin Vladim Tags: Article Source Type: research
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