Cancers, Vol. 12, Pages 216: Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer

Cancers, Vol. 12, Pages 216: Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer Cancers doi: 10.3390/cancers12010216 Authors: Olga S. Kolovskaya Tatiana N. Zamay Galina S. Zamay Vasily A. Babkin Elena N. Medvedeva Nadezhda A. Neverova Andrey K. Kirichenko Sergey S. Zamay Ivan N. Lapin Evgeny V. Morozov Alexey E. Sokolov Andrey A. Narodov Dmitri G. Fedorov Felix N. Tomilin Vladimir N. Zabluda Yulia Alekhina Kirill A. Lukyanenko Yury E. Glazyrin Valery A. Svetlichnyi Maxim V. Berezovski Anna S. Kichkailo Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magne...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research