High-Risk and Hepatitis C –Positive Organ Donors: Current Practice in Heart, Lung, and Liver Transplantation

THE UNITED Network for Organ Sharing (UNOS) adopted the label “high risk” from the Public Health Service (PHS) in 2004 in order to improve organ safety by reducing disease transmission. This has resulted in nonutilization of organs from patients who are otherwise healthy but deemed high risk because of social behaviors or illicit drug use. Organ availabili ty remains the limiting factor to organ transplantation, and the number of patients awaiting transplantation is outpacing the number of transplantations being performed.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Review Article Source Type: research

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This study found that DAA-induced SVR in patients with hepatitis C is associated with a reduced risk of variceal bleeding, among both patients with and without established cirrhosis.Alimentary Pharmacology &Therapeutics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
For more information go tohttps://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 3/4/2020 12:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Fewer than a quarter of infants exposed perinatally to hepatitis C virus (HCV) undergo testing for the virus, according to a database study.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Gastroenterology News Source Type: news
What is the impact of delaying treatment for different populations of people living with hepatitis C? The authors present a clinical decision tool for informing treatment timing decisions.Liver International
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Gastroenterology Journal Article Source Type: news
For patients with liver disease from hepatitis C virus (HCV) infection complicated by end-stage renal disease (ESRD), it is important to assess liver fibrosis before kidney transplantation. We evaluated the accuracy of non-invasive tests to identify advanced hepatic fibrosis in patients with HCV and ESRD.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
by Robin A. Welsh, Nianbin Song, Catherine A. Foss, Tatiana Boronina, Robert N. Cole, Scheherazade Sadegh-Nasseri DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medulla and B cells. Previous reports have suggested possible links between DO and autoimmunity, Hepatitis C (HCV) infection, a nd cancer, but the mechanism of how DO contributes to these diseases remains unclear. Here, using a combination of various in vivo approaches, including peptide elution, mixed lymphocyte reaction, T-cell receptor (TC...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
ConclusionsTransplanting kidneys from HCV-viremic donors into HCV-uninfected recipients increased quality-adjusted life expectancy and reduced costs compared with a strategy of transplanting kidneys from HCV-unexposed donors.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionsIn HCV GT1- and GT2-infected Japanese patients, treatment with JNJ-4178 was well tolerated and resulted in 100% of patients achieving SVR12.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Bacterial, viral, or overall infection was associated with increased Parkinson's disease risk.Helicobacter pylori, hepatitis C virus, Malassezia, and pneumoniae infection were positively associated with the risk of Parkinson's disease. However, infection of herpes virus, hepatitis B virus, pertussis, scarlet fever, mumps, chicken pox, influenza virus, measles, and German measles was not. AbstractAimsRecent studies showed that patients with various bacterial, viral, and fungal infections might be at increased risk of Parkinson's disease (PD). However, the risk of PD in patients with each specific infection varied. This meta...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSION: This generic sofosbuvir was well absorbed, the plasma concentration was increased with an increased dose, and it was safe in healthy subjects. A high-fat meal appeared to promote the bioavailability of sofosbuvir and the metabolite GS-566500.
. PMID: 32053101 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
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