On virus growth and form

Publication date: Available online 15 January 2020Source: Physics ReportsAuthor(s): Roya Zandi, Bogdan Dragnea, Alex Travesset, Rudolf PodgornikAbstractWe review approaches aimed at deciphering the physical mechanisms responsible for viral structure and assembly. We discuss the basic principles of condensed matter physics, macroscopic electrostatics and elastomechanics as they apply to nanosized two-dimensional biomolecular shells with spherical topology and icosahedral symmetry, as well as their proper extension to nonspherical structures pertinent to retroviruses. We examine the relation between the virus structure, the physical interactions that are driving their (self)assembly and the thermodynamics of transition from an isotropic protein solution to the assembled shell state, and discuss the driving forces for large-scale structural reorganizations characterizing maturation processes in the already assembled nano-shells. We furthermore review physical models corresponding to the condensed states of confined genome-carrying biopolymers in viral nano-shells during virus self-assembly and host-cell infection processes, and show how the combination of discrete and continuum coarse grained mechanics, commonly used in the fundamental physical description of viruses, together with the pertinent description of generic long-range electrostatic and specific short-range interactions give insight into the details of structural order and mechanical properties of viruses and elucidate...
Source: Physics Reports - Category: Physics Source Type: research

Related Links:

Authors: Lisicki M, Schoenen J Abstract Introduction: Most preventive migraine treatments modify the brain's excitation/inhibition balance and/or serotonin metabolism, which likely accounts for their unfavourable adverse effect profile. Novel biological therapies blocking CGRP transmission are effective and much better tolerated, but they are expensive and may not influence brain dysfunctions upstream in the pathophysiological cascade of migraine, including premonitory and aura symptoms. Biochemical and clinical studies suggest that there may be another complimentary treatment strategy, the one that targets the undere...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Ankur Khajuria
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical exc...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s):
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s):
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Matthew J Rowland, Tonny Veenith, Peter J Hutchinson, Gavin D Perkins, SOS Trial Investigators
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Joanna Laurson-Doube, Nick Rijke, Kathleen Costello, Jennifer McDonell, Gavin Giovannoni, Brenda Banwell, Peer Baneke
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Peter J Goadsby, Ali R Rezai, David W Dodick
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Arne May
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Steven C Cramer
Source: The Lancet Neurology - Category: Neurology Source Type: research
More News: Nanotechnology | Physics