Molecules, Vol. 25, Pages 359: Correlations Between Trace Elements in Selected Locations of the Human Brain in Individuals with Alcohol Use Disorder

Molecules, Vol. 25, Pages 359: Correlations Between Trace Elements in Selected Locations of the Human Brain in Individuals with Alcohol Use Disorder Molecules doi: 10.3390/molecules25020359 Authors: Cezary Grochowski Magdalena Szukała Jakub Litak Agnieszka Budny Jędrzej Proch Dariusz Majerek Eliza Blicharska Przemysław Niedzielski Trace element distribution varies in different locations of the human brain. Several elements were found to cause various negative effects, such as neurodegeneration. In this paper, we analyzed the interactions between seven trace elements: zinc (Zn), selenium (Se), manganese (Mg), iron (Fe), copper (Cu), chromium (Cr) and cobalt (Co) in individuals with alcohol use disorder (AUD) and individuals without (control group). Brain tissue samples from 31 individuals with AUD and 31 control subjects were harvested. Inductively coupled plasma optical emission spectrometry was used for trace element determination. In the control group, there were several positive correlations between Cr, Cu, Fe and Mn. In the AUD group, positive correlations between Co and Cr, Cu, Fe, Mn, Zn were found. The majority of correlations between Zn and other elements are positive. In the studied group, Mn had strong positive correlations with Co, Cr, Cu and Fe. The strongest positive correlation found between average element concentration was between Cu and Cr. The knowledge of kinetics and metabolism of trace elements as well as the impact of alcohol on ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research