Human mesenchymal stem cells encapsulated-coacervated photoluminescent nanodots layered bioactive chitosan/collagen hydrogel matrices to indorse cardiac healing after acute myocardial infarction

Publication date: Available online 15 January 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Rui Si, Chao Gao, Rui Guo, Chen Lin, Jiayi Li, Wenyi GuoAbstractAcute Myocardial Infarction (MI) is one of the foremost causes of human death worldwide and it leads to mass death of cardiomyocytes, interchanges of unfavorable biological environment and affecting electrical communications by fibrosis scar formations, and specifically deficiency of blood supply to heart which leads to heart damage and heart failure. Recently, numerous appropriate strategies have been applied to base on solve these problems wound be provide prominent therapeutic potential to cardiac regeneration after acute MI. In the present study, a combined biopolymeric conductive hydrogel was fabricated with conductive ultra-small graphene quantum dots as a soft injectable hydrogel for cardiac regenerations. The resultant hydrogel was combined with human Mesenchymal stem cells (hMSCs) to improved angiogenesis in cardiovascular tissues and decreasing cardiomyocyte necrosis of hydrogel treated acute-infarcted region has been greatly associated with the development of cardiac functions in MI models. The prepared graphene quantum dots and hydrogel groups was physico-chemically analyzed and confirmed the suitability of the materials for cardiac regeneration applications. The in vitro analyzes of hydrogels with hMSCs have established that enhanced cell survival rate, increased expressions of pr...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research