Excitotoxicity as a Target against Neurodegenerative Processes.

Excitotoxicity as a Target against Neurodegenerative Processes. Curr Pharm Des. 2020 Jan 13;: Authors: Binvignat O, Olloquequi J Abstract The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the aging of population. Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as to the injury and death of neurons due to an excessive or prolonged exposure to excitatory amino acids, has been shown to play a pivotal role. The increased release and/or decreased uptake of glutamate results in a dysregulation of neuronal calcium homeostasis, leading to oxidative stress, mitochondrial dysfunctions, disturbances in protein turn-over and neuroinflammation. Despite the anti-excitotoxic drug memantine has shown modest beneficial effects in some patients with dementia, to date, there is no effective treatment capable of halting or curing neurodegenerative diseases such as Alzheimer's disease, Parkinson disease, Huntington's disease or amyotrophic lateral sclerosis. This has led to a growing body of research focusing on understanding the mechanisms associated to the excitotoxic insult and on uncovering potential therapeutic strategies targeting these mechanisms. In the present review, we examine the molecular mechanisms related to the excitotoxic cell death. Moreover, we provide a comprehensive and updated state of the art of preclinical and clinical investigations targeting e...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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