Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model

ConclusionsOverall, our study confirms thatNf1+/ − mice exhibit deficits in behavioral inhibition in multiple contexts, a key feature of ADHD, and can be used as a model system to identify alterations in neural circuitry associated with symptoms of ADHD in children with NF1.

Source: Journal of Neurodevelopmental Disorders - January 14, 2020 Category: Neurology Source Type: research