The increased IL-17-producing γδT cells promote tumor cell proliferation and migration in neuroblastoma.

In this study, we found an augment of IL-17+ γδT cells both in in vitro PAM-stimulated γδT-cell expanding culture and circulating γδT cells in NB patients. These patient-origin cells expanded in vitro by PAM in the presence of IL-17 polarizing condition were shown to promote the proliferation and migration of NB cells. Furthermore, an intrinsic preference for IL-17 polarization in NB γδT cells was revealed by mRNA microarray and Western Blot, which pointed to an up-regulated expression of multiple Th17-development related genes in addition to an increased phosphorylation level of STAT3.
PMID: 31931123 [PubMed - as supplied by publisher]

Source: Clinical Immunology - January 9, 2020 Category: Allergy & Immunology Authors: Zhang H, Chai W, Yang W, Han W, Mou W, Xi Y, Chen X, Wang H, Wang W, Qin H, Wang H, Ma X, Wang X, Gui J Tags: Clin Immunol Source Type: research