Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing

Publication date: Available online 15 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Brian C. Gilmour, Ruben Gudmundsrud, Johannes Frank, Amund Hov, Sofie Hindkjær Lautrup, Yahyah Aman, Helge Røsjø, Charles Brenner, Mathias Ziegler, Ole-Bjørn Tysnes, Charalampos Tzoulis, Torbjørn Omland, Arne Søraas, Trygve Holmøy, Linda H. Bergersen, Jon Storm-Mathisen, Hilde Nilsen, Evandro F. FangAbstractNicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to apoptosis and autophagic pathways. The importance of NAD+ in ageing and healthy longevity has been revealed from laboratory animal studies and early-stage clinical testing. While basic researchers and clinicians have investigated the molecular mechanisms and translation potential of NAD+, there are still major gaps in applying laboratory science to design the most effective trials. This mini-review was based on the programme and discussions of the 3rd NO-Age Symposium held at the Akershus University Hospital, Norway on the 28th October 2019. This symposium brought together leading basic researchers on NAD+, and clinicians who are leading or are going to perform NAD+ augmentation-related clinical studies. This meeting covered talks about NAD+ synthetic pathways, subcellular homeostasis of NAD+, benefits of NA...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research

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