No Barrett’s—No Cancer: A Proposed New Paradigm for Prevention of Esophageal Adenocarcinoma

Esophageal adenocarcinoma is inflammation-associated cancer with a recognizable preneoplastic stage, Barrett’s. Barrett’s describes the metaplastic transformation of esophageal squamous mucosa into columnar epithelium that typically results secondary to mucosal damage caused by acidic gastroduodenal reflux. Continued acid reflux may then result in mucosal inflammation which results in progressive inflammation-induced genetic instability that may eventuate in esophageal adenocarcinoma. Barrett’s is the only recognized precursor lesion to esophageal carcinoma. Barrett’s mucosa is unique among preneoplastic lesions; ablation therapy results in restitution of a squamous epithelium reducing or eliminating accumulated genetic instabilities and resetting the biological clock progressing toward invasive cancer. However, recurrence of Barrett’s after ablation is common. We propose that both Barrett’s and recurrence of Barrett’s after ablation can be prevented and discuss how current approaches to therapy for gastroesophageal reflux disease, for Barrett’s screening, chemoprevention, and ablation therapy all might be reconsidered. We propose (1) improved approaches to Barrett’s prevention, (2) universal Barrett’s screening by linking Barrett’s screening to colon cancer screening, (3) ablation of all Barrett’s mucosa along with (4) acid-suppressive–antireflux therapy tailored to prevent development of Barrett’s or the recurrence of Barrett’s after ablation t...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research