The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS

Conclusion: Special population plasma did not affect quantitation of drugs with a wide range of plasma protein binding levels in human plasma. With the confirmation that there is no impact on quantification from the matrix, the bioanalytical method can be used to support the pharmacokinetic evaluations for clinical studies in special populations.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research