Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study

ConclusionUsing a comprehensiveCYP2D6 genotyping panel, the present study demonstrates a>  6-fold increase of dose-adjusted plasma metoprolol trough concentration in CYP2D6 PMs vs. EMs with a parallel lower increase in achieved maximum HR during exercise but without association between genotype and frequency or severity of self-reported adverse drug effects. This may indicate that CYP2 D6 PMs potentially could benefit of the increased plasma concentration per dose in a naturalistic setting.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research