Comparison of alpha-spending plans for near real-time monitoring for Guillain-Barr é after influenza vaccination during the 2010/11 influenza season.

CONCLUSIONS: A constant alpha-spending plan appears to be robust, in terms of power and time to detect a signal, across a range of these parameters, including alternate monitoring start dates based on either cumulative vaccinations or GBS claims observed, frequency of monitoring, hypothetical relative risks, and vaccine uptake patterns. PMID: 31932134 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31932134?dopt=Abstract

Source: Vaccine - January 9, 2020 Category: Allergy & Immunology Authors: Sandhu SK, Hua W, MaCurdy TE, Franks RL, Avagyan A, Chillarige Y, Wernecke M, Kelman J, Ball R Tags: Vaccine Source Type: research