Impact of Medications for Opioid Use Disorder on Discharge Against Medical Advice Among People Who Inject Drugs Hospitalized for Infective Endocarditis.

CONCLUSION AND SCIENTIFIC SIGNIFICANCE: PWID hospitalized for endocarditis are at high risk for discharge AMA but more research is needed to understand the impact of MOUD. (Am J Addict 2020;00:00-00). PMID: 31930608 [PubMed - as supplied by publisher]
Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research

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Morbidity and mortality from opioid use disorder (OUD) remain at epidemic levels in the United States. In the 12-month period ending July 2018, approximately 46,000 people died from opioid overdose in the United States, approximately five deaths every hour.[1] The harms of OUD extend beyond the well-publicized overdose deaths. Aside from the tragic toll on families, patients experience social and medical sequelae of drug use. Among the medical sequelae is drug use-associated infective endocarditis, whose incidence has risen dramatically where opioid use disorder (OUD) is endemic; at least one state experienced a tenfold in...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
We appreciated Yanagawa's paper about the still poorly understood factors involved in tricuspid valve (TV) infective endocarditis (IE) among injective drugs abusers [1]. Right-sided IE is exceptional in non-drug addicts and in those without implanted devices, since reduced pressure/hematic turbulence/oxygen saturation exerts a protective effect against valvar infections [2].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research
AbstractPurpose of ReviewInfective endocarditis (IE) is a significant risk and complication in patients with a history of intravenous (IV) drug use (DU), and treatments are becoming more invasive as infections become more serious. IV drug use is an extremely addictive behavior and challenging behavior to address, and patients are at high risk of relapse to IV drug use even after successful IE treatment. Addressing the underlying cause with behavioral modification is essential to prevent behavior and subsequent infection recurrence. Treatments depend on a multidisciplinary approach to address the physiologic and underlying ...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
In response to the recently published article by Tiako et al, “Recidivism is the Leading Cause of Death Among Intravenous Drug Users Who Underwent Cardiac Surgery for Infective Endocarditis,” we strongly oppose the use of the word “recidivism” to characterize the population of patients who continue to use intravenous drugs after valve surgery for endoc arditis. This term, which suggests a criminal re-offense, perpetuates the mischaracterization of people who use intravenous drugs as criminals. We encourage de-stigmatization of this population through the use of terms that acknowledge that addiction ...
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ADULT – Letter to the Editor Source Type: research
In Reply In discussing the topic of injection drug use –associated infective endocarditis in our review, our intent was to highlight the lack of certainty with respect to the use of surgery and outcomes in these patients. Cardiac surgery in patients with injection drug use–associated infective endocarditis has been associated with higher mortality a nd reoperation in the first 6 months after surgery than in patients with infective endocarditis not related to injection drug use. Surgical decision-making about infective endocarditis is complicated in general. For example, approximately 1 in 4 patients with infect...
Source: JAMA - Category: General Medicine Source Type: research
Injection drug use (IDU) is a growing public health threat in Virginia, though there is limited knowledge of related morbidity. The purpose of this study was to describe the temporal, geographic and clinical t...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
This report describes a case of bleeding pulmonary arterial pseudoaneurysm in a young, drug-addicted woman with tricuspid annuloplasty after infective endocarditis that was promptly identified by computed tomography pulmonary angiography and successfully treated using coil embolization. Perfusion scintigraphy at 30 days confirmed the safety of endovascular treatment.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We report the case of a 36-year-old female with active injection drug use who developed methicillin-sensitive Staphylococcus aureus IE of the tricuspid valve. Associated with poor adherence to medical therapy as a consequence of opioid addiction, she developed septic emboli to the lungs and an intravascular abscess in the left main pulmonary artery. These long-term potentially fatal, sequelae of incompletely treated IE require surgical intervention, as medical therapy is unlikely to be sufficient. Surgical management may involve TV replacement, pulmonary artery resection, and pneumonectomy. Prevention of these complication...
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: August 2018Source: Journal of Forensic and Legal Medicine, Volume 58Author(s): Shashank Tyagi, Swati Patki, Pradeep Vaideeswar, Vikas MeshramAbstractInvolvement of both right and left heart chambers with infective endocarditis is extremely rare. In this case report, we aimed to present a rare case of Infective endocarditis (IE) in an intravenous &inhalational drug misuse involving both cardiac chambers with incidental pneumoconiosis.
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
We report the case of a 36-year-old female with active injection drug use who developed methicillin-sensitive Staphylococcus aureus IE of the tricuspid valve. Associated with poor adherence to medical therapy as a consequence of opioid addiction, she developed septic emboli to the lungs and an intravascular abscess in the left main pulmonary artery. These long-term potentially fatal, sequelae of incompletely treated IE require surgical intervention, as medical therapy is unlikely to be sufficient. Surgical management may involve TV replacement, pulmonary artery resection, and pneumonectomy. Prevention of these complication...
Source: IDCases - Category: Infectious Diseases Source Type: research
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