The Treatment of Bipolar Depression: Current Status and Future Perspectives

AbstractPurpose of ReviewThis paper aims to review current available treatment options and to consider future directions in the treatment of bipolar depression.Recent FindingsThere are a limited number of established treatments that have demonstrated varied efficacy in acute bipolar depression including modern antipsychotics (quetiapine, lurasidone, olanzapine ± fluoxetine and recently cariprazine) and mood stabilisers (lamotrigine and valproate). Lithium has a role in protecting against depressive relapses and suicide. Alternative and experimental treatments including pramipexole, modafinil/armodafinil, omega-3 fatty acids and thyroxine may be used to a ugment the treatment of bipolar depression. Ketamine represents a major breakthrough, producing rapid reductions in depressive symptoms even in cases of treatment-resistance, but challenges remain in how best to maintain response and reduce unwanted side effects.SummaryThere remains uncertainty with regard to the relative efficacy and safety of established and experimental treatments for bipolar depression. Further work using consistent, optimal trial designs as well as further investigation into novel compounds and treatment interventions is warranted.
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research

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Over this past weekend, I participated in my first outreach event for Mental Health America at the NBC4 Telemundo 44 Health and Fitness Expo in Washington, D.C.  Dr. Martin Luther King said that people “fear each other because they do not know each other.  They do not know each other because they do not communicate with each other.”  Here is what I learned at the event: it is easy to communicate with people about mental health because the topic is accessible across culture, race and age. In addition, talking about mental health is especially important to those with mental illness. We had a s...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Conferences General Mental Health America Mental Health and Wellness Policy and Advocacy Publishers connection Mental Health Advocacy Mental Health Policy Source Type: blogs
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
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Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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