An overview of lipoxygenase inhibitors with approach of in vivo studies

Publication date: Available online 14 January 2020Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Ala Orafaie, Mina Mousavian, Hossein Orafai, Hamid SadeghianAbstractLipoxygenases (LOXs) are enzymes which found in organisms that catalyze the peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of the mentioned enzymes and their metabolites in formation of sensitivities, inflammations, many of cancers (prostate, breast, etc), obesity, diabetes and atherosclerosis had been demonstrated. This review aimed to focus on research findings introducing proved LOXs (5/12/15-LOX) inhibitors, which have been involved in in vivo studies, and discuss on their sources, chemical structures and medicinal applications. By this subject selection, we would introduce the possible LOXs inhibitors (5/12/15-LOX) with special physiological and metabolic levels and open a vision in molecular target selection for the readers.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research