SEM and qRT-PCR revealed quercetin inhibits morphogenesis of Aspergillus flavus conidia via modulating calcineurin-Crz1 signalling pathway

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Source: Mycology - Category: Biology Authors: Source Type: research

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The ability of fungi to sense environmental stressors and appropriately respond is linked to secretory system functions. The dermatophyte infection process depends on an orchestrated signaling regulation that triggers the transcription of genes responsible for adherence and penetration of the pathogen into host-tissue. A high secretion system is activated to support the host-pathogen interaction and assures maintenance of the dermatophyte infection. The gateway of secretion machinery is the endoplasmic reticulum (ER), which is the primary site for protein folding and transport. Current studies have shown that ER stress tha...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, three major SGs, i.e., glucosides of β-sitosterol, stigmasterol, and campesterol, were synthesized and used as standards for measurement of their contents in rice bran (RB)-based fermented food (FBRA) utilizing Aspergillus oryzae and raw material (RM). The compounds were quantified using liquid chromatography/electrospray ionization-tandem mass spectrometry. It was found that β-sitosteryl glucoside was most abundant among the analyzed glucosides in both samples, and the contents of each SG in FBRA decreased about 35% from those of RM. In contrast to SGs, the contents of ASGs in FBRA increased 1.5-f...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 February 2020Source: Food ControlAuthor(s): Luísa Freire, Patrícia A.C. Braga, Marianna M. Furtado, Jeany Delafiori, Flávia L. Dias-Audibert, Giuliano E. Pereira, Felix G. Reyes, Rodrigo R. Catharino, Anderson S. Sant’AnaAbstractThe presence of ochratoxin A (OTA) in wine is mainly due to the contamination of grapes by Aspergillus carbonarius and A. niger, still in the vineyard or at stages prior to winemaking. Throughout winemaking process, although there is a reduction in OTA levels, modified mycotoxins may also be formed. In fact, modified mycotoxins are co...
Source: Food Control - Category: Food Science Source Type: research
n Bills Aspergillus pachycristatus is an industrially important fungus for the production of the antifungal echinocandin B and is closely related to model organism A. nidulans. Its secondary metabolism is largely unknown except for the production of echinocandin B and sterigmatocystin. We constructed mutants for three genes that regulate secondary metabolism in A. pachycristatus NRRL 11440, and evaluated the secondary metabolites produced by wild type and mutants strains. The secondary metabolism was explored by metabolic networking of UPLC-HRMS/MS data. The genes and metabolites of A. pachycristatus were compared t...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
This study provides a solid evidence to discover the biological functions of histone methyltransferase in pathogenic fungi.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Aspergilloma, also known as mycetoma or fungus ball, is the most common manifestation of pulmonary involvement by Aspergillus species. The fungal ball typically forms within preexisting cavities of the lungs. Diagnosis requires both radiographic evidence along with serologic or microbiologic evidence of Aspergillus species involvement. While clinical features such as hemoptysis, chest pain, shortness of breath, cough, and fever are helpful in diagnosis, they are non-specific symptoms. Surgery is currently the mainstay of treatment for aspergilloma but is associated with considerable mortality and morbidity.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Review article Source Type: research
Publication date: Available online 15 February 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Harshitha Madhusoodan Jathanna, Chandrayan Vaman Rao, Louella Concepta GoveasAbstractBiofuels and their production is the need of the hour considering the current fuel crisis. In this regard, ways of mitigating biodiesel production costs is being actively researched upon. With the same intention, in the present work, an investigation was carried out to test the capability of utilizing the hydrolysates of de-oiled Pongamia seed cake, a byproduct of biodiesel, for microbial lipid production using Aspergillus ochra...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Authors: Meyer D, Smit DP Abstract Both infective and neoplastic eyelid and orbital conditions in human immunodeficiency virus (HIV) infected patients are often the result of opportunistic or co-infections (OI). In most cases, these clinical findings in younger patients alert the physician to suspected underlying HIV infection. When the eyelids and periorbital skin are primarily involved in OI with varicella-zoster virus it is called Herpes Zoster Ophthalmicus. Co-infection with a Pox virus manifests as molluscum contagiosum eruptions. Orbital cellulitis is secondary to various organisms (Mycobacterium tuberculosis...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Authors: Díaz Alcázar MDM, Ruiz Escolano E, Casado Caballero FJ, Cervilla Sáez de Tejada E Abstract A 72-year-old female presented with abdominal pain and constipation and intestinal dilation was found. Abdominal computed tomography showed two areas of thickening and stenosis in the proximal jejunum and preterminal ileum, with an unknown etiology. Exploratory laparotomy was proposed but the patient suffered a sudden and progressive decrease in consciousness. Cranial computed tomography showed an ischemic area and a midline shift. Brain biopsies suggested infection by Aspergillus Fumigatus. Desp...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
Publication date: March 2020Source: Biocatalysis and Agricultural Biotechnology, Volume 24Author(s): Ashraf S.A. El-Sayed, Ahmed H. Moustafa, Hussein A. Hussein, Aly A. El-Sheikh, Samah N. El-Shafey, Nahla A.M. Fathy, Gamal A. EnanAbstractSpodoptera littoralis has been recognized as the major destructive cause of various economic crops in Egypt. Chemical insecticides have been frequently used, however, the development of insecticidal resistance is the current challenge, thus searching for novel ecofriendly biocontrol agents is the prospective challenge. Fungal endophytes of plants have been recognized as a repertoire for b...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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